Encephalitogenic T-cells increase numbers of CNS T-cells regardless of antigen specificity by both increasing T-cell entry and preventing egress

Jason R. Lees, Julia Sim, John H. Russell

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

This study utilized an adoptive transfer model of experimental autoimmune encephalomyelitis (EAE) induction in mice to characterize the mechanisms involved in CNS accumulation of transferred and host T-cells. Using a flow cytometric technique, we examined phenotypic characteristics of CNS T-cells following disease initiation and the role of T-cell activation in CNS invasion and retention. Host T-cell activation increased cell recruitment and EAE severity. CNS antigen specific T-cells were required to induce T-cell retention within the CNS. Once retention was initiated, CNS T-cells were retained regardless of specificity. This study characterizes mechanisms involved in CNS accumulation of T-cells during EAE pathogenesis.

Original languageEnglish
Pages (from-to)10-16
Number of pages7
JournalJournal of Neuroimmunology
Volume220
Issue number1-2
DOIs
StatePublished - Mar 30 2010

Keywords

  • Cell retention
  • Cell trafficking
  • EAE
  • Multiple sclerosis
  • T-cells

Fingerprint Dive into the research topics of 'Encephalitogenic T-cells increase numbers of CNS T-cells regardless of antigen specificity by both increasing T-cell entry and preventing egress'. Together they form a unique fingerprint.

  • Cite this