Enantioselective synthesis of (+)-(2S,3s)-3-ethynyltyrosine

Antony N. Shaw, Roland E. Dolle, Lawrence I. Kruse

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Homochiral ethynyl tyrosine 2, designed as a potential dopamine β-hydroxylase irreversible inhibitor prodrug, has been synthesised asymmetrically in 15-steps, using the alkylation and azidation of acylated oxazolidones to establish relative and absolute stereochemistry.

Original languageEnglish
Pages (from-to)5081-5084
Number of pages4
JournalTetrahedron Letters
Issue number35
StatePublished - 1990


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