Enabling Technologies for Personalized and Precision Medicine

Dean Ho, Stephen R. Quake, Edward R.B. McCabe, Wee Joo Chng, Edward K. Chow, Xianting Ding, Bruce D. Gelb, Geoffrey S. Ginsburg, Jason Hassenstab, Chih Ming Ho, William C. Mobley, Garry P. Nolan, Steven T. Rosen, Patrick Tan, Yun Yen, Ali Zarrinpar

Research output: Contribution to journalReview article

Abstract

Individualizing patient treatment is a core objective of the medical field. Reaching this objective has been elusive owing to the complex set of factors contributing to both disease and health; many factors, from genes to proteins, remain unknown in their role in human physiology. Accurately diagnosing, monitoring, and treating disorders requires advances in biomarker discovery, the subsequent development of accurate signatures that correspond with dynamic disease states, as well as therapeutic interventions that can be continuously optimized and modulated for dose and drug selection. This work highlights key breakthroughs in the development of enabling technologies that further the goal of personalized and precision medicine, and remaining challenges that, when addressed, may forge unprecedented capabilities in realizing truly individualized patient care.

Original languageEnglish
Pages (from-to)497-518
Number of pages22
JournalTrends in Biotechnology
Volume38
Issue number5
DOIs
StatePublished - May 2020

Keywords

  • artificial intelligence
  • clinical trials
  • diagnostics
  • personalized medicine
  • precision medicine
  • therapeutics

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  • Cite this

    Ho, D., Quake, S. R., McCabe, E. R. B., Chng, W. J., Chow, E. K., Ding, X., Gelb, B. D., Ginsburg, G. S., Hassenstab, J., Ho, C. M., Mobley, W. C., Nolan, G. P., Rosen, S. T., Tan, P., Yen, Y., & Zarrinpar, A. (2020). Enabling Technologies for Personalized and Precision Medicine. Trends in Biotechnology, 38(5), 497-518. https://doi.org/10.1016/j.tibtech.2019.12.021