Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance

Stephen Y. Liang, Anand Kumar

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Mortality and morbidity in severe sepsis and septic shock remain high despite significant advances in critical care. Efforts to improve outcome in septic conditions have focused on targeted, quantitative resuscitation strategies utilizing intravenous fluids, vasopressors, inotropes, and blood transfusions to correct disease-associated circulatory dysfunction driven by immune-mediated systemic inflammation. This review explores an alternate paradigm of septic shock in which microbial burden is identified as the key driver of mortality and progression to irreversible shock. We propose that clinical outcomes in severe sepsis and septic shock hinge upon the optimized selection, dosing, and delivery of highly potent antimicrobial therapy.

Original languageEnglish
Article number36
JournalCurrent Infectious Disease Reports
Volume17
Issue number7
DOIs
StatePublished - Jul 4 2015

Keywords

  • Antibiotic
  • Antimicrobial
  • Combination therapy
  • Infection
  • Pharmacokinetics
  • Sepsis
  • Septic shock
  • Survival

Fingerprint

Dive into the research topics of 'Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance'. Together they form a unique fingerprint.

Cite this