TY - JOUR
T1 - Emigration of monocyte-derived cells to lymph nodes during resolution of inflammation and its failure in atherosclerosis
AU - Randolph, Gwendalyn J.
PY - 2008/10
Y1 - 2008/10
N2 - Purpose of review This review compares the fate of monocyte-derived cells that enter atherosclerotic plaques with those that accumulate at other sites of inflammation. Recent findings Resolution of inflammatory reactions involves emigration of monocyte-derived cells out of the inflamed site through nearby lymphatic vessels. However, this emigratory process associated with resolution is impaired in atherosclerosis. The mechanism for impeded emigration from plaques in vivo remains to be determined, but multiple factors are likely involved, including specialized properties of artery walls and a negative impact of lipid mediators on monocyte-derived cell migration. Summary Impaired egress would be expected to compound macrophage accumulation within plaques, contribute to build-up of necrotic pools, and explain in part the reticence of many plaques to regress, or resolve. Restoration of the capacity of monocyte-derived cells to leave plaques would, by contrast, be expected to facilitate regression, but it remains to be determined whether restoring egress may sometimes provoke unwanted outcomes as well.
AB - Purpose of review This review compares the fate of monocyte-derived cells that enter atherosclerotic plaques with those that accumulate at other sites of inflammation. Recent findings Resolution of inflammatory reactions involves emigration of monocyte-derived cells out of the inflamed site through nearby lymphatic vessels. However, this emigratory process associated with resolution is impaired in atherosclerosis. The mechanism for impeded emigration from plaques in vivo remains to be determined, but multiple factors are likely involved, including specialized properties of artery walls and a negative impact of lipid mediators on monocyte-derived cell migration. Summary Impaired egress would be expected to compound macrophage accumulation within plaques, contribute to build-up of necrotic pools, and explain in part the reticence of many plaques to regress, or resolve. Restoration of the capacity of monocyte-derived cells to leave plaques would, by contrast, be expected to facilitate regression, but it remains to be determined whether restoring egress may sometimes provoke unwanted outcomes as well.
KW - Chronic inflammation
KW - Dendritic cells
KW - Lymphatic
KW - Macrophages
KW - Migration
UR - http://www.scopus.com/inward/record.url?scp=53549093848&partnerID=8YFLogxK
U2 - 10.1097/MOL.0b013e32830d5f09
DO - 10.1097/MOL.0b013e32830d5f09
M3 - Review article
C2 - 18769227
AN - SCOPUS:53549093848
SN - 0957-9672
VL - 19
SP - 462
EP - 468
JO - Current opinion in lipidology
JF - Current opinion in lipidology
IS - 5
ER -