Emerging themes in cryptococcal capsule synthesis

Pardeep Kumar, Meng Yang, Brian C. Haynes, Michael L. Skowyra, Tamara L. Doering

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Cryptococcus neoformans, a basidiomycete yeast and opportunistic pathogen, expends significant biosynthetic effort on construction of a polysaccharide capsule with a radius that may be many times that of the cell. Beyond posing a stimulating challenge in terms of defining biosynthetic pathways, the capsule is required for this yeast to cause fatal disease. This combination has focused the attention of researchers on this system. Here we briefly review two aspects of the rapidly advancing field of capsule synthesis: the extensive variation that occurs in capsule polymers and the regulation of capsule biosynthesis.

Original languageEnglish
Pages (from-to)597-602
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume21
Issue number5
DOIs
StatePublished - Oct 2011

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