Emerging Targets for Cardiovascular Disease Prevention in Diabetes

Nathan O. Stitziel, Jenny E. Kanter, Karin E. Bornfeldt

Research output: Contribution to journalReview article

Abstract

Type 1 and type 2 diabetes mellitus (T1DM and T2DM) increase the risk of atherosclerotic cardiovascular disease (CVD), resulting in acute cardiovascular events, such as heart attack and stroke. Recent clinical trials point toward new treatment and prevention strategies for cardiovascular complications of T2DM. New antidiabetic agents show unexpected cardioprotective benefits. Moreover, genetic and reverse translational strategies have revealed potential novel targets for CVD prevention in diabetes, including inhibition of apolipoprotein C3 (APOC3). Modeling and pharmacology-based approaches to improve insulin action provide additional potential strategies to combat CVD. The development of new strategies for improved diabetes and lipid control fuels hope for future prevention of CVD associated with diabetes.

Original languageEnglish
JournalTrends in Molecular Medicine
DOIs
StateAccepted/In press - Jan 1 2020

Keywords

  • angiopoietin-like
  • apolipoprotein C3
  • atherosclerosis
  • diabetes
  • genetics
  • insulin

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