Emerging solutions for the dilated native right ventricular outflow tract

Transcatheter pulmonary valve replacement in the dysfunctional native right ventricular outflow tract (RVOT) provides an ongoing challenge. Currently available transcatheter pulmonary valves were developed for implantation within surgically placed conduits and bioprosthetic valves, and are often inadequately sized for the dilated native RVOT. The Medtronic Harmony™ (Medtronic, Minneapolis, MN), the Alterra Adaptive Prestent™ (Edwards Life Sciences, Irvine, CA), and the Venus P-valve™ (Venus Medtech, Shanghai, China) are three devices that have been developed in recent years, for the dedicated indication of transcatheter pulmonary valve replacement in the dysfunctional native RVOT. In this article, we describe each of these devices and review the clinical experience with them to date.