TY - JOUR
T1 - Emerging roles of the bone morphogenetic protein pathway in cancer
T2 - Potential therapeutic target for kinase inhibition
AU - Jiramongkolchai, Pawina
AU - Owens, Philip
AU - Hong, Charles C.
N1 - Publisher Copyright:
© 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
PY - 2016/8/15
Y1 - 2016/8/15
N2 - Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-β (TGF-β) family signalling pathway. Similar to TGF-β, the complex roles of BMPs in development and disease are demonstrated by their dichotomous roles in various cancers and cancer stages. Although early studies implicated BMP signalling in tumour suppressive phenotypes, the results of more recent experiments recognize BMPs as potent tumour promoters. Many of these complexities are becoming illuminated by understanding the role of BMPs in their contextual role in unique cell types of cancer and the impact of their surrounding tumour microenvironment. Here we review the emerging roles of BMP signalling in cancer, with a focus on the molecular underpinnings of BMP signalling in individual cancers as a valid therapeutic target for cancer prevention and treatment.
AB - Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-β (TGF-β) family signalling pathway. Similar to TGF-β, the complex roles of BMPs in development and disease are demonstrated by their dichotomous roles in various cancers and cancer stages. Although early studies implicated BMP signalling in tumour suppressive phenotypes, the results of more recent experiments recognize BMPs as potent tumour promoters. Many of these complexities are becoming illuminated by understanding the role of BMPs in their contextual role in unique cell types of cancer and the impact of their surrounding tumour microenvironment. Here we review the emerging roles of BMP signalling in cancer, with a focus on the molecular underpinnings of BMP signalling in individual cancers as a valid therapeutic target for cancer prevention and treatment.
KW - Bone morphogenetic protein (bmp) signalling
KW - Cancer
KW - Small molecule bmp inhibitors
UR - http://www.scopus.com/inward/record.url?scp=85009743263&partnerID=8YFLogxK
U2 - 10.1042/BST20160069
DO - 10.1042/BST20160069
M3 - Review article
C2 - 27528760
AN - SCOPUS:85009743263
SN - 0300-5127
VL - 44
SP - 1117
EP - 1134
JO - Biochemical Society transactions
JF - Biochemical Society transactions
IS - 4
ER -