Emerging Research Directions in Adult Congenital Heart Disease A Report from an NHLBI/ACHA Working Group

Michelle Gurvitz, Kristin M. Burns, Ralph Brindis, Craig S. Broberg, Curt J. Daniels, Stephanie M.P.N. Fuller, Margaret A. Honein, Paul Khairy, Karen S. Kuehl, Michael J. Landzberg, William T. Mahle, Douglas L. Mann, Ariane Marelli, Jane W. Newburger, Gail D. Pearson, Randall C. Starling, Glenn R. Tringali, Anne Marie Valente, Joseph C. Wu, Robert M. Califf

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations


Congenital heart disease (CHD) is the most common birth defect, affecting about 0.8% of live births. Advances in recent decades have allowed >85% of children with CHD to survive to adulthood, creating a growing population of adults with CHD. Little information exists regarding survival, demographics, late outcomes, and comorbidities in this emerging group, and multiple barriers impede research in adult CHD. The National Heart, Lung, and Blood Institute and the Adult Congenital Heart Association convened a multidisciplinary working group to identify high-impact research questions in adult CHD. This report summarizes the meeting discussions in the broad areas of CHD-related heart failure, vascular disease, and multisystem complications. High-priority subtopics identified included heart failure in tetralogy of Fallot, mechanical circulatory support/transplantation, sudden cardiac death, vascular outcomes in coarctation of the aorta, late outcomes in single-ventricle disease, cognitive and psychiatric issues, and pregnancy.

Original languageEnglish
Pages (from-to)1956-1964
Number of pages9
JournalJournal of the American College of Cardiology
Issue number16
StatePublished - Apr 26 2016


  • congenital
  • heart defects
  • outcomes
  • pregnancy
  • single ventricle
  • sudden cardiac death
  • tetralogy of Fallot


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