Abstract
Recent advancements in the molecular understanding of pediatric brain tumor biology have significantly contributed to the development of innovative therapeutic strategies aimed at improving clinical outcomes for affected children. These scientific breakthroughs have facilitated the identification of specific molecular targets and signaling pathways integral to the oncogenesis of pediatric brain tumors, thereby enabling the design of targeted therapies that disrupt these pathogenic processes. Furthermore, the incorporation of immunotherapy and precision medicine approaches has unveiled novel therapeutic avenues, offering the potential for more efficacious and less toxic treatment modalities. As research in this domain continues to progress, these cutting-edge therapeutic interventions are anticipated to enhance survival rates and improve the quality of life for pediatric patients. This review delineates emerging interventional treatments in pediatric brain tumor management and examines the persistent challenges within the field.
| Original language | English |
|---|---|
| Pages (from-to) | 359-427 |
| Number of pages | 69 |
| Journal | Advances in Cancer Research |
| Volume | 167 |
| DOIs | |
| State | Published - Jan 1 2025 |
Keywords
- Adoptive cellular immunotherapy
- Convection-enhanced delivery (CED)
- Laser interstitial thermal therapy (LITT)
- Sonodynamic therapy
- Targeted small-molecule inhibitors
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