Emerging interventional treatments in the management of pediatric brain tumors

Research output: Contribution to journalArticlepeer-review

Abstract

Recent advancements in the molecular understanding of pediatric brain tumor biology have significantly contributed to the development of innovative therapeutic strategies aimed at improving clinical outcomes for affected children. These scientific breakthroughs have facilitated the identification of specific molecular targets and signaling pathways integral to the oncogenesis of pediatric brain tumors, thereby enabling the design of targeted therapies that disrupt these pathogenic processes. Furthermore, the incorporation of immunotherapy and precision medicine approaches has unveiled novel therapeutic avenues, offering the potential for more efficacious and less toxic treatment modalities. As research in this domain continues to progress, these cutting-edge therapeutic interventions are anticipated to enhance survival rates and improve the quality of life for pediatric patients. This review delineates emerging interventional treatments in pediatric brain tumor management and examines the persistent challenges within the field.

Original languageEnglish
Pages (from-to)359-427
Number of pages69
JournalAdvances in Cancer Research
Volume167
DOIs
StatePublished - Jan 1 2025

Keywords

  • Adoptive cellular immunotherapy
  • Convection-enhanced delivery (CED)
  • Laser interstitial thermal therapy (LITT)
  • Sonodynamic therapy
  • Targeted small-molecule inhibitors

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