Emerging insights into the molecular and cellular basis of glioblastoma

Gavin P. Dunn, Mikael L. Rinne, Jill Wykosky, Giannicola Genovese, Steven N. Quayle, Ian F. Dunn, Pankaj K. Agarwalla, Milan G. Chheda, Benito Campos, Alan Wang, Cameron Brennan, Keith L. Ligon, Frank Furnari, Webster K. Cavene, Ronald A. Depinho, Lynda Chin, William C. Hah

Research output: Contribution to journalArticlepeer-review

402 Scopus citations

Abstract

Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive multiplatform genomic characterization has provided a higher-resolution picture of the molecular alterations underlying this disease. These studies provide the emerging view that "glioblastoma" represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions.

Original languageEnglish
Pages (from-to)756-784
Number of pages29
JournalGenes and Development
Volume26
Issue number8
DOIs
StatePublished - 2012

Keywords

  • Angiogenesis
  • Glioblastoma
  • Glioma classification
  • Idh1
  • Invasion
  • Tumor-initiating cells

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