Emerging insights into the molecular and cellular basis of glioblastoma

Gavin P. Dunn; Mikael L. Rinne; Jill Wykosky; Giannicola Genovese; Steven N. Quayle; Ian F. Dunn; Pankaj K. Agarwalla; Milan G. Chheda; Benito Campos; Alan Wang; Cameron Brennan; Keith L. Ligon; Frank Furnari; Webster K. Cavene; Ronald A. Depinho; Lynda Chin; William C. Hah

doi:10.1101/gad.187922.112

Emerging insights into the molecular and cellular basis of glioblastoma

Gavin P. Dunn, Mikael L. Rinne, Jill Wykosky, Giannicola Genovese, Steven N. Quayle, Ian F. Dunn, Pankaj K. Agarwalla, Milan G. Chheda, Benito Campos, Alan Wang, Cameron Brennan, Keith L. Ligon, Frank Furnari, Webster K. Cavene, Ronald A. Depinho, Lynda Chin, William C. Hah

Research output: Contribution to journal › Article › peer-review

471 Scopus citations

Abstract

Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive multiplatform genomic characterization has provided a higher-resolution picture of the molecular alterations underlying this disease. These studies provide the emerging view that "glioblastoma" represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions.

Original language	English
Pages (from-to)	756-784
Number of pages	29
Journal	Genes and Development
Volume	26
Issue number	8
DOIs	https://doi.org/10.1101/gad.187922.112
State	Published - 2012

Keywords

Angiogenesis
Glioblastoma
Glioma classification
Idh1
Invasion
Tumor-initiating cells

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10.1101/gad.187922.112

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Dunn, G. P., Rinne, M. L., Wykosky, J., Genovese, G., Quayle, S. N., Dunn, I. F., Agarwalla, P. K., Chheda, M. G., Campos, B., Wang, A., Brennan, C., Ligon, K. L., Furnari, F., Cavene, W. K., Depinho, R. A., Chin, L., & Hah, W. C. (2012). Emerging insights into the molecular and cellular basis of glioblastoma. Genes and Development, 26(8), 756-784. https://doi.org/10.1101/gad.187922.112

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AU - Quayle, Steven N.

AU - Dunn, Ian F.

AU - Agarwalla, Pankaj K.

AU - Chheda, Milan G.

AU - Campos, Benito

AU - Wang, Alan

AU - Brennan, Cameron

AU - Ligon, Keith L.

AU - Furnari, Frank

AU - Cavene, Webster K.

AU - Depinho, Ronald A.

AU - Chin, Lynda

AU - Hah, William C.

PY - 2012

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KW - Angiogenesis

KW - Glioblastoma

KW - Glioma classification

KW - Idh1

KW - Invasion

KW - Tumor-initiating cells

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JO - Genes and Development

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Emerging insights into the molecular and cellular basis of glioblastoma

Abstract

Keywords

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