Emerging drug therapies for benign prostatic hyperplasia

Travis L. Bullock, Gerald L. Andriole

Research output: Contribution to journalReview article

43 Scopus citations

Abstract

Benign prostatic hyperplasia (BPH) is the nonmalignant enlargement of the prostate gland caused by increases in number of both epithelial and stromal cells. Clinically, BPH leads to voiding dysfunction, which is most often referred to as lower urinary tract symptoms (LUTS). Historically, the only treatments for LUTS due to BPH were watchful waiting or surgery (transurethral or open prostatectomy). However, over the last 20 years medical therapy has taken a prominent role in the management of BPH. Current medical treatments for BPH include α-adrenergic receptor antagonists, inhibitors of the 5-α reductase enzyme and various phytotherapies. These agents are generally effective and safe; however, many patients are unable to tolerate the side effects or are refractory to medical management and require surgery. In light of this, many potential new therapies for the treatment of BPH are under development. Some represent a variation of current treatments, whereas others target novel molecular pathways within the prostate. The aim of this review is to examine current pharmacotherapies as well as to highlight emerging drugs that may improve our treatment of patients with LUTS secondary to BPH.

Original languageEnglish
Pages (from-to)111-123
Number of pages13
JournalExpert Opinion on Emerging Drugs
Volume11
Issue number1
DOIs
StatePublished - Mar 1 2006

Keywords

  • 5-α reductase inhibitors
  • BPH therapy
  • Benign prostatic hyperplasia
  • α-adrenergic antagonists

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