TY - JOUR
T1 - Emergence of Klebsiella pneumoniae co-producing NDM-1, OXA-48, CTX-M-15, CMY-16, QnrA and ArmA in Switzerland
AU - Seiffert, Salome N.
AU - Marschall, Jonas
AU - Perreten, Vincent
AU - Carattoli, Alessandra
AU - Furrer, Hansjakob
AU - Endimiani, Andrea
N1 - Funding Information:
Funding: This work was supported by internal funds from the Institute of Infectious Diseases of Bern (IFIK) and by grant 1.12.06 (2012–2014) from the Swiss Veterinary Federal Office (BVET). SNS is a PhD student supported by IFIK and BVET.
Publisher Copyright:
Copyright © 2014 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Extensively drug-resistant (XDR) Klebsiella pneumoniae isolates usually carry a single carbapenemase (e.g. KPC, NDM, OXA-48-like). Here we describe an XDR K. pneumoniae of sequence type 101 that was detected in the screening rectal swab of a patient transferred from the intensive care unit of a hospital located in Belgrade (Serbia) to Bern University Hospital (Switzerland). The isolate was resistant to all antibiotics with the exception of colistin [minimum inhibitory concentration] (MIC ≤ 0.125 μg/mL), tigecycline (MIC = 0.5 μg/mL) and fosfomycin (MIC = 2 μg/mL). The isolate co-possessed class B (NDM-1) and class D (OXA-48) carbapenemases, class A extended-spectrum β-lactamase (CTX-M-15), class C cephalosporinase (CMY-16), ArmA 16S rRNA methyltransferase, substitutions in GyrA and ParC, loss of OmpK35 porin, as well as other genes conferring resistance to quinolones (qnrA), tetracyclines [tet(A)], sulfonamides (sul1, sul2), trimethoprim (dfrA12, dfrA14), rifampicin (arr-1), chloramphenicol (cmlA1, floR) and streptomycin (aadA1). The patient was placed under contact isolation precautions preventing the spread of this nearly untreatable pathogen.
AB - Extensively drug-resistant (XDR) Klebsiella pneumoniae isolates usually carry a single carbapenemase (e.g. KPC, NDM, OXA-48-like). Here we describe an XDR K. pneumoniae of sequence type 101 that was detected in the screening rectal swab of a patient transferred from the intensive care unit of a hospital located in Belgrade (Serbia) to Bern University Hospital (Switzerland). The isolate was resistant to all antibiotics with the exception of colistin [minimum inhibitory concentration] (MIC ≤ 0.125 μg/mL), tigecycline (MIC = 0.5 μg/mL) and fosfomycin (MIC = 2 μg/mL). The isolate co-possessed class B (NDM-1) and class D (OXA-48) carbapenemases, class A extended-spectrum β-lactamase (CTX-M-15), class C cephalosporinase (CMY-16), ArmA 16S rRNA methyltransferase, substitutions in GyrA and ParC, loss of OmpK35 porin, as well as other genes conferring resistance to quinolones (qnrA), tetracyclines [tet(A)], sulfonamides (sul1, sul2), trimethoprim (dfrA12, dfrA14), rifampicin (arr-1), chloramphenicol (cmlA1, floR) and streptomycin (aadA1). The patient was placed under contact isolation precautions preventing the spread of this nearly untreatable pathogen.
KW - 16S rRNA
KW - AmpC
KW - Carbapenemase
KW - ESBL
KW - MBL
UR - http://www.scopus.com/inward/record.url?scp=85027927397&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2014.05.008
DO - 10.1016/j.ijantimicag.2014.05.008
M3 - Article
C2 - 25123809
AN - SCOPUS:85027927397
SN - 0924-8579
VL - 44
SP - 260
EP - 262
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - 3
ER -