TY - JOUR
T1 - Embryo morphology and live birth in the United States
AU - Awadalla, Michael S.
AU - Ho, Jacqueline R.
AU - McGinnis, Lynda K.
AU - Ahmady, Ali
AU - Cortessis, Victoria K.
AU - Paulson, Richard J.
N1 - Funding Information:
The authors thank SART for the dataset as well as all SART members for providing clinical information to the SART CORS database for use by patients and researchers. Without the efforts of SART members, this research would not have been possible.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/6
Y1 - 2022/6
N2 - Objective: To determine the best-fit live birth rate per embryo based on maternal age, embryo stage, and embryo morphology. Design: Retrospective data analysis. Setting: Fertility clinics. Patient(s): The patients included were treated with in vitro fertilization in the United States at clinics reporting data to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System. We analyzed live birth data of unbiopsied autologous cleavage and blastocyst stage embryos for cycles started from 2016 through 2018. The analysis included 223,377 embryo transfers with a total of 336,888 embryos. Intervention(s): None. Main Outcome Measure(s): Live birth rate per embryo and rate of multiple gestations per pregnancy. Result(s): At the mean maternal age of 34 years, fresh embryos produced live birth rates of 19%, 38%, 26%, and 27% for embryos aged 3, 5, 6, and 7 days, respectively. At the age 34 years, live birth rates for day 5 fresh embryos by overall morphology grade were 43% for good, 30% for fair, and 21% for poor. For the transfer of 2 fresh day 5 blastocysts, the rate of multiple gestations per pregnancy was 47% at 25 years old, 44% at 30 years old, 35% at 35 years old, and 23% at 40 years old. Conclusion(s): The analysis of pregnancy data in the Society for Assisted Reproductive Technology database can be used to calculate live birth rates per embryo based on maternal age, embryo age, and morphology. This information can be used for evidence-based decision making, quality control, and planning multicenter studies.
AB - Objective: To determine the best-fit live birth rate per embryo based on maternal age, embryo stage, and embryo morphology. Design: Retrospective data analysis. Setting: Fertility clinics. Patient(s): The patients included were treated with in vitro fertilization in the United States at clinics reporting data to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System. We analyzed live birth data of unbiopsied autologous cleavage and blastocyst stage embryos for cycles started from 2016 through 2018. The analysis included 223,377 embryo transfers with a total of 336,888 embryos. Intervention(s): None. Main Outcome Measure(s): Live birth rate per embryo and rate of multiple gestations per pregnancy. Result(s): At the mean maternal age of 34 years, fresh embryos produced live birth rates of 19%, 38%, 26%, and 27% for embryos aged 3, 5, 6, and 7 days, respectively. At the age 34 years, live birth rates for day 5 fresh embryos by overall morphology grade were 43% for good, 30% for fair, and 21% for poor. For the transfer of 2 fresh day 5 blastocysts, the rate of multiple gestations per pregnancy was 47% at 25 years old, 44% at 30 years old, 35% at 35 years old, and 23% at 40 years old. Conclusion(s): The analysis of pregnancy data in the Society for Assisted Reproductive Technology database can be used to calculate live birth rates per embryo based on maternal age, embryo age, and morphology. This information can be used for evidence-based decision making, quality control, and planning multicenter studies.
KW - In vitro fertilization
KW - blastocyst stage
KW - cleavage stage
KW - embryo morphology
KW - live birth
UR - https://www.scopus.com/pages/publications/85128686899
U2 - 10.1016/j.xfre.2022.02.006
DO - 10.1016/j.xfre.2022.02.006
M3 - Article
C2 - 35789729
AN - SCOPUS:85128686899
SN - 2666-3341
VL - 3
SP - 131
EP - 137
JO - F and S Reports
JF - F and S Reports
IS - 2
ER -