Elucidation of the receptor-bound conformation of the enkephalins

F. A. Gorin, T. M. Balasubramanian, C. D. Barry, G. R. Marshall

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

The biologically relevant conformers of enkephalin predicted by solid state, solution state, and theoretical energy studies have been compared with the published structure-activity data on these compounds. No confirmational technique proposes a model consistent with all the pharmacological data; the shortcomings of each approach are evaluated. An alternative approach, which correlates the structure-activity data of opiate compounds with that of the enkephalins, is described and shown to produce a model consistent with the available structure-activity data.

Original languageEnglish
Pages (from-to)27-39
Number of pages13
JournalJournal of Supramolecular and Cellular Biochemistry
Volume9
Issue number1
StatePublished - Dec 1 1979

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