Elucidation of the bioactive conformation of the N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine class of μ-opioid receptor antagonists

Bertrand Le Bourdonnec, Allan J. Goodman, Mathieu Michaut, Hai Fen Ye, Thomas M. Graczyk, Serge Belanger, Torsten Herbertz, Glenn P.A. Yap, Robert N. DeHaven, Roland E. Dolle

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25 Scopus citations

Abstract

The series of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines have been widely investigated as opioid receptor antagonists. One of our research goals was to explore the bioactive conformation of the N-phenethyl trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine derivative 3, prototypical μ-opioid antagonist in this series. In this effort, the rotational degrees of freedom of the N-substituent of 3 were limited by incorporation of an ethylene bridge between the piperidine 2- or 6-position of 3 and the benzylic position of the N-phenethyl moiety. The overall modification led to a novel series of fused bicyclic derivatives of the octahydroquinolizine chemical class, conformationally restricted analogue of 3. The constrained analogues 6 and 9 showed high affinity toward the μ-opioid receptor. Compound 6 was found to be a μ-opioid antagonist, whereas the constrained analogue 9 displayed potent μ-agonist activity in vitro. This study provides additional information about the molecular determinants for μ recognition, the structural features affecting ligand binding, and the structure function relationships.

Original languageEnglish
Pages (from-to)7278-7289
Number of pages12
JournalJournal of Medicinal Chemistry
Volume49
Issue number25
DOIs
StatePublished - Dec 14 2006

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