TY - JOUR
T1 - Elimination of contaminant kryptofix 2.2.2 in the routine production of 2-[18F]fluoro-2-deoxy-d-glucose
AU - Moerlein, Stephen M.
AU - Brodack, James W.
AU - Siegel, Barry A.
AU - Welch, Michael J.
N1 - Funding Information:
Acknowledgements--The authors thank Mr K. Lechner for performing the HPLC quality control testing of 2-\[ISF\]FDG, and Mr J. Robison and Mr W. Margenau for the cyclotron production of \[~SF\]fluoride.T his work was supported by NIH Grants HL13851 and NS06833, and by a grant from the Edward Mallinckrodt, Jr Foundation.
PY - 1989
Y1 - 1989
N2 - Radiopharmaceutical solutions of 2-[18F]fluoro-2-deoxy-d-glucose (2-[18F]FDG) prepared via an aminopolyether-supported nucleophilic-substitution mechanism were analyzed for contaminant 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo-[8,8,8]-hexacosane (Kryptofix 2.2.2). Washing the C18-immobilized [18F]fluoro-tetraacetylated intermediate with 10 mL 0.1 M HCl was found to remove impurity Kryptofix 2.2.2 from the final product. Inclusion of this synthetic step allowed the robotic production of drug-quality 2-[18F]FDG in 52-56% radiochemical yield within 75 min. A thin-layer chromatographic system for the clinical screening of the radiochemical and chemical purity of this radiopharmaceutical is described.
AB - Radiopharmaceutical solutions of 2-[18F]fluoro-2-deoxy-d-glucose (2-[18F]FDG) prepared via an aminopolyether-supported nucleophilic-substitution mechanism were analyzed for contaminant 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo-[8,8,8]-hexacosane (Kryptofix 2.2.2). Washing the C18-immobilized [18F]fluoro-tetraacetylated intermediate with 10 mL 0.1 M HCl was found to remove impurity Kryptofix 2.2.2 from the final product. Inclusion of this synthetic step allowed the robotic production of drug-quality 2-[18F]FDG in 52-56% radiochemical yield within 75 min. A thin-layer chromatographic system for the clinical screening of the radiochemical and chemical purity of this radiopharmaceutical is described.
UR - http://www.scopus.com/inward/record.url?scp=0024467630&partnerID=8YFLogxK
U2 - 10.1016/0883-2889(89)90090-7
DO - 10.1016/0883-2889(89)90090-7
M3 - Article
C2 - 2559062
AN - SCOPUS:0024467630
SN - 0883-2889
VL - 40
SP - 741
EP - 743
JO - International Journal of Radiation Applications and Instrumentation. Part
JF - International Journal of Radiation Applications and Instrumentation. Part
IS - 9
ER -