Elevated Troponin-T levels in patients requiring prolonged mechanical ventdlatory support (MVS)

John M. Clochesy, Susan M. Sereika, John Gorcsan, Adelaida M. Miro, Margaret Ann Carno

Research output: Contribution to journalArticlepeer-review


Introduction: Identifying non-pulmonary determinants is essential in liberating those ventilator-dependent patients, who despite demonstrating good pulmonary mechanics, are unable to resume unassisted, spontaneous ventilation. Prior research suggests heart function is one of these non-pulmonary determinants. Methods: As part of a larger study, blood was obtained from 19 subjects (10 men, 9 women)on Day 1 of MVS. They ranged in age from 21 to 89 years (mean=62.5). There were 11 medical and 8 surgical patients. Myocardial injury was evaluated using Troponin-T level (TnT). Results: Of 19 subjects, 6 had elevated TnT. Three of those with elevated TnT (>0.10 μg/L) had CK-MB and ECG evidence of MI, 3 did not. There was a significant difference in the duration of MVS between those who had elevated TnT (mean-18 days, median=20 days) and those who did not (mean=4 days, median = 3 days) and survival distribution functions as demonstrated by Kaplan Meier survival function plot [Generalized Savage log-rank test=6.55, df=1, p<.05]. Conclusions: Clinically recognized as well as unrecognized myocardial injury (ischemia or infarction) is related to prolonged MVS.

Original languageEnglish
Pages (from-to)A163
JournalCritical care medicine
Issue number1 SUPPL.
StatePublished - Dec 1 1999
Externally publishedYes


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