Elevated oxysterol and N-palmitoyl-O-phosphocholineserine levels in congenital disorders of glycosylation

An N. Dang Do; Irene J. Chang; Xutian Jiang; Lynne A. Wolfe; Bobby G. Ng; Christina Lam; Rhonda E. Schnur; Katrina Allis; Hana Hansikova; Nina Ondruskova; Shawn D. O'Connor; Amarilis Sanchez-Valle; Arve Vollo; Raymond Y. Wang; Zoe Wolfenson; John Perreault; Daniel S. Ory; Hudson H. Freeze; J. Lawrence Merritt; Forbes D. Porter

doi:10.1002/jimd.12595

Elevated oxysterol and N-palmitoyl-O-phosphocholineserine levels in congenital disorders of glycosylation

An N. Dang Do, Irene J. Chang, Xutian Jiang, Lynne A. Wolfe, Bobby G. Ng, Christina Lam, Rhonda E. Schnur, Katrina Allis, Hana Hansikova, Nina Ondruskova, Shawn D. O'Connor, Amarilis Sanchez-Valle, Arve Vollo, Raymond Y. Wang, Zoe Wolfenson, John Perreault, Daniel S. Ory, Hudson H. Freeze, J. Lawrence Merritt, Forbes D. Porter

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Congenital disorders of glycosylation (CDG) and Niemann-Pick type C (NPC) disease are inborn errors of metabolism that can both present with infantile-onset severe liver disease and other multisystemic manifestations. Plasma bile acid and N-palmitoyl-O-phosphocholineserine (PPCS) are screening biomarkers with proposed improved sensitivity and specificity for NPC. We report an infant with ATP6AP1-CDG who presented with cholestatic liver failure and elevated plasma oxysterols and bile acid, mimicking NPC clinically and biochemically. On further investigation, PPCS, but not the bile acid derivative N-(3β,5α,6β-trihydroxy-cholan-24-oyl) glycine (TCG), were elevated in plasma samples from individuals with ATP6AP1-, ALG1-, ALG8-, and PMM2-CDG. These findings highlight the importance of keeping CDG within the diagnostic differential when evaluating children with early onset severe liver disease and elevated bile acid or PPCS to prevent delayed diagnosis and treatment.

Original language	English
Pages (from-to)	326-334
Number of pages	9
Journal	Journal of Inherited Metabolic Disease
Volume	46
Issue number	2
DOIs	https://doi.org/10.1002/jimd.12595
State	Published - Mar 2023

Keywords

ATP6AP1
N-palmitoyl-O-phosphocholineserine (PPCS)
Niemann-pick type C (NPC)
bile acids
congenital disorders of glycosylation (CDG)
oxysterols

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10.1002/jimd.12595

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Dang Do, A. N., Chang, I. J., Jiang, X., Wolfe, L. A., Ng, B. G., Lam, C., Schnur, R. E., Allis, K., Hansikova, H., Ondruskova, N., O'Connor, S. D., Sanchez-Valle, A., Vollo, A., Wang, R. Y., Wolfenson, Z., Perreault, J., Ory, D. S., Freeze, H. H., Merritt, J. L., & Porter, F. D. (2023). Elevated oxysterol and N-palmitoyl-O-phosphocholineserine levels in congenital disorders of glycosylation. Journal of Inherited Metabolic Disease, 46(2), 326-334. https://doi.org/10.1002/jimd.12595

@article{efb68a840c704241a29e1ff91e2ff872,

title = "Elevated oxysterol and N-palmitoyl-O-phosphocholineserine levels in congenital disorders of glycosylation",

abstract = "Congenital disorders of glycosylation (CDG) and Niemann-Pick type C (NPC) disease are inborn errors of metabolism that can both present with infantile-onset severe liver disease and other multisystemic manifestations. Plasma bile acid and N-palmitoyl-O-phosphocholineserine (PPCS) are screening biomarkers with proposed improved sensitivity and specificity for NPC. We report an infant with ATP6AP1-CDG who presented with cholestatic liver failure and elevated plasma oxysterols and bile acid, mimicking NPC clinically and biochemically. On further investigation, PPCS, but not the bile acid derivative N-(3β,5α,6β-trihydroxy-cholan-24-oyl) glycine (TCG), were elevated in plasma samples from individuals with ATP6AP1-, ALG1-, ALG8-, and PMM2-CDG. These findings highlight the importance of keeping CDG within the diagnostic differential when evaluating children with early onset severe liver disease and elevated bile acid or PPCS to prevent delayed diagnosis and treatment.",

keywords = "ATP6AP1, N-palmitoyl-O-phosphocholineserine (PPCS), Niemann-pick type C (NPC), bile acids, congenital disorders of glycosylation (CDG), oxysterols",

author = "{Dang Do}, {An N.} and Chang, {Irene J.} and Xutian Jiang and Wolfe, {Lynne A.} and Ng, {Bobby G.} and Christina Lam and Schnur, {Rhonda E.} and Katrina Allis and Hana Hansikova and Nina Ondruskova and O'Connor, {Shawn D.} and Amarilis Sanchez-Valle and Arve Vollo and Wang, {Raymond Y.} and Zoe Wolfenson and John Perreault and Ory, {Daniel S.} and Freeze, {Hudson H.} and Merritt, {J. Lawrence} and Porter, {Forbes D.}",

note = "Publisher Copyright: {\textcopyright} 2023 SSIEM. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.",

year = "2023",

month = mar,

doi = "10.1002/jimd.12595",

language = "English",

volume = "46",

pages = "326--334",

journal = "Journal of Inherited Metabolic Disease",

issn = "0141-8955",

number = "2",

}

Dang Do, AN, Chang, IJ, Jiang, X, Wolfe, LA, Ng, BG, Lam, C, Schnur, RE, Allis, K, Hansikova, H, Ondruskova, N, O'Connor, SD, Sanchez-Valle, A, Vollo, A, Wang, RY, Wolfenson, Z, Perreault, J, Ory, DS, Freeze, HH, Merritt, JL & Porter, FD 2023, 'Elevated oxysterol and N-palmitoyl-O-phosphocholineserine levels in congenital disorders of glycosylation', Journal of Inherited Metabolic Disease, vol. 46, no. 2, pp. 326-334. https://doi.org/10.1002/jimd.12595

TY - JOUR

T1 - Elevated oxysterol and N-palmitoyl-O-phosphocholineserine levels in congenital disorders of glycosylation

AU - Dang Do, An N.

AU - Chang, Irene J.

AU - Jiang, Xutian

AU - Wolfe, Lynne A.

AU - Ng, Bobby G.

AU - Lam, Christina

AU - Schnur, Rhonda E.

AU - Allis, Katrina

AU - Hansikova, Hana

AU - Ondruskova, Nina

AU - O'Connor, Shawn D.

AU - Sanchez-Valle, Amarilis

AU - Vollo, Arve

AU - Wang, Raymond Y.

AU - Wolfenson, Zoe

AU - Perreault, John

AU - Ory, Daniel S.

AU - Freeze, Hudson H.

AU - Merritt, J. Lawrence

AU - Porter, Forbes D.

PY - 2023/3

Y1 - 2023/3

N2 - Congenital disorders of glycosylation (CDG) and Niemann-Pick type C (NPC) disease are inborn errors of metabolism that can both present with infantile-onset severe liver disease and other multisystemic manifestations. Plasma bile acid and N-palmitoyl-O-phosphocholineserine (PPCS) are screening biomarkers with proposed improved sensitivity and specificity for NPC. We report an infant with ATP6AP1-CDG who presented with cholestatic liver failure and elevated plasma oxysterols and bile acid, mimicking NPC clinically and biochemically. On further investigation, PPCS, but not the bile acid derivative N-(3β,5α,6β-trihydroxy-cholan-24-oyl) glycine (TCG), were elevated in plasma samples from individuals with ATP6AP1-, ALG1-, ALG8-, and PMM2-CDG. These findings highlight the importance of keeping CDG within the diagnostic differential when evaluating children with early onset severe liver disease and elevated bile acid or PPCS to prevent delayed diagnosis and treatment.

AB - Congenital disorders of glycosylation (CDG) and Niemann-Pick type C (NPC) disease are inborn errors of metabolism that can both present with infantile-onset severe liver disease and other multisystemic manifestations. Plasma bile acid and N-palmitoyl-O-phosphocholineserine (PPCS) are screening biomarkers with proposed improved sensitivity and specificity for NPC. We report an infant with ATP6AP1-CDG who presented with cholestatic liver failure and elevated plasma oxysterols and bile acid, mimicking NPC clinically and biochemically. On further investigation, PPCS, but not the bile acid derivative N-(3β,5α,6β-trihydroxy-cholan-24-oyl) glycine (TCG), were elevated in plasma samples from individuals with ATP6AP1-, ALG1-, ALG8-, and PMM2-CDG. These findings highlight the importance of keeping CDG within the diagnostic differential when evaluating children with early onset severe liver disease and elevated bile acid or PPCS to prevent delayed diagnosis and treatment.

KW - ATP6AP1

KW - N-palmitoyl-O-phosphocholineserine (PPCS)

KW - Niemann-pick type C (NPC)

KW - bile acids

KW - congenital disorders of glycosylation (CDG)

KW - oxysterols

UR - http://www.scopus.com/inward/record.url?scp=85147528807&partnerID=8YFLogxK

U2 - 10.1002/jimd.12595

DO - 10.1002/jimd.12595

M3 - Article

C2 - 36719165

AN - SCOPUS:85147528807

SN - 0141-8955

VL - 46

SP - 326

EP - 334

JO - Journal of Inherited Metabolic Disease

JF - Journal of Inherited Metabolic Disease

IS - 2

ER -

Elevated oxysterol and N-palmitoyl-O-phosphocholineserine levels in congenital disorders of glycosylation

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