Elevated Levels of Soluble Interleukin-2 Receptors in Multiple Sclerosis

Steven J. Greenberg, Luisa Marcon, Barrie J. Hurwitz, Thomas A. Waldmann, David L. Nelson, John L. Trotter, Roel C. Van Der Veen, David B. Clifford

Research output: Contribution to journalLetterpeer-review

81 Scopus citations


To the Editor: The expansion of activated, antigen-reactive T-cell populations is dependent on the sequential induction and expression of interleukin-2 (T-cell growth factor) and the interleukin-2 receptor, and the subsequent binding of interleukin-2 to its high-affinity membrane receptor. In a letter in the May 5 issue,1 Trotter and colleagues have shown elevated serum levels of interleukin-2 in patients with chronic progressive multiple sclerosis. Their findings may reflect a state of ongoing lymphocyte activation, suggesting a commensurate induction and expression of interleukin-2 receptor on circulating T lymphocytes. The high-affinity interleukin-2 receptor is composed of at least two different interleukin-2–binding peptides —.

Original languageEnglish
Pages (from-to)1019-1020
Number of pages2
JournalNew England Journal of Medicine
Issue number15
StatePublished - Oct 13 1988


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