Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis

John R. Rinker, Kathryn Trinkaus, Anne H. Cross

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels ≥ 1.53 μg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).

Original languageEnglish
Pages (from-to)1288-1290
Number of pages3
JournalNeurology
Volume67
Issue number7
DOIs
StatePublished - Oct 2006

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