Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis

John R. Rinker, Kathryn Trinkaus, Anne H. Cross

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels ≥ 1.53 μg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).

Original languageEnglish
Pages (from-to)1288-1290
Number of pages3
JournalNeurology
Volume67
Issue number7
DOIs
StatePublished - Oct 2006

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