Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis

John R. Rinker; Kathryn Trinkaus; Anne H. Cross

doi:10.1212/01.wnl.0000238107.31364.21

Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis

John R. Rinker, Kathryn Trinkaus, Anne H. Cross

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels ≥ 1.53 μg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).

Original language	English
Pages (from-to)	1288-1290
Number of pages	3
Journal	Neurology
Volume	67
Issue number	7
DOIs	https://doi.org/10.1212/01.wnl.0000238107.31364.21
State	Published - Oct 2006

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title = "Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis",

abstract = "Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels ≥ 1.53 μg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).",

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AU - Cross, Anne H.

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AB - Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels ≥ 1.53 μg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%).

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JO - Neurology

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Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis

Abstract

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