TY - JOUR
T1 - Electrotonic cell-cell interactions in cardiac tissue
T2 - Effects on action potential propagation and repolarization
AU - Rudy, Yoram
PY - 2005
Y1 - 2005
N2 - This article characterizes through computer simulations, the role of cell-cell interactions and of tissue structure in determining properties of action potential propagation and repolarization in cardiac tissue. The results demonstrate strong interactions between membrane excitatory processes and electrical loading by the passive tissue structure. These interactions modulate the ionic mechanism of conduction and influence conduction velocity and robustness. Cell-cell interactions also have a strong effect on the dispersion of repolarization in cardiac tissue.
AB - This article characterizes through computer simulations, the role of cell-cell interactions and of tissue structure in determining properties of action potential propagation and repolarization in cardiac tissue. The results demonstrate strong interactions between membrane excitatory processes and electrical loading by the passive tissue structure. These interactions modulate the ionic mechanism of conduction and influence conduction velocity and robustness. Cell-cell interactions also have a strong effect on the dispersion of repolarization in cardiac tissue.
KW - Cardiac action potential
KW - Cardiac arrhythmias
KW - Gap junctions
KW - Tissue structure
UR - http://www.scopus.com/inward/record.url?scp=23744452788&partnerID=8YFLogxK
U2 - 10.1196/annals.1341.027
DO - 10.1196/annals.1341.027
M3 - Article
C2 - 16093506
AN - SCOPUS:23744452788
SN - 0077-8923
VL - 1047
SP - 308
EP - 313
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -