Electrospun PLGA Nanofiber Scaffolds Release Ibuprofen Faster and Degrade Slower After In Vivo Implantation

Corinne N. Riggin, Feini Qu, Dong Hwa Kim, Julianne Huegel, David R. Steinberg, Andrew F. Kuntz, Louis J. Soslowsky, Robert L. Mauck, Joseph Bernstein

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

While delayed delivery of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with improved tendon healing, early delivery has been associated with impaired healing. Therefore, NSAID use is appropriate only if the dose, timing, and mode of delivery relieves pain but does not impede tissue repair. Because delivery parameters can be controlled using drug-eluting nanofibrous scaffolds, our objective was to develop a scaffold for local controlled release of ibuprofen (IBP), and characterize the release profile and degradation both in vitro and in vivo. We found that when incubated in vitro in saline, scaffolds containing IBP had a linear release profile. However, when implanted subcutaneously in vivo or when incubated in vitro in serum, scaffolds showed a rapid burst release. These data demonstrate that scaffold properties are dependent on the environment in which they are placed and the importance of using serum, rather than saline, for initial in vitro evaluation of biofactor release from biodegradable scaffolds.

Original languageEnglish
Pages (from-to)2348-2359
Number of pages12
JournalAnnals of biomedical engineering
Volume45
Issue number10
DOIs
StatePublished - Oct 1 2017

Keywords

  • NSAID
  • Polymer scaffold
  • Tendon healing

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