Electrophysiological evidence for a rapid membrane action of the gonadal steroid, 17β-estradiol, on CA1 pyramidal neurons of the rat hippocampus

Micheal Wong, Robert L. Moss

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114 Scopus citations

Abstract

The rapid electrophysiological effects of 17β-estradiol on CA1 pyramidal neurons (n = 86) were investigated utilizing intracellular recording from the rat hippocampal slice preparation. Bath application of 17β-estradiol, but not 17α-estradiol, caused a reversible depolarization and increased input resistance with a latency of less than 1 min in 19.8% of CA1 neurons tested. There was no significant difference in the percentage of estradiol-responsive cells between male and female rats. Estradiol-responsive cells were identified from prepubertal female rats, as well as females in all stages of the estrous cycle. 17β-estradiol had no effect on the slow afterhyperpolarization or accommodative properties of CA1 neurons. In 2 out of 4 cells tested, the specific antiestrogen, tamoxifen, blocked the excitatory response to 17β-estradiol.

Original languageEnglish
Pages (from-to)148-152
Number of pages5
JournalBrain Research
Volume543
Issue number1
DOIs
StatePublished - Mar 8 1991

Keywords

  • CA1 pyramidal neuron
  • Estradiol
  • Hippocampal slice
  • Intracellular recording
  • Tamoxifen

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