Electrophysiological correlates of the brain's intrinsic large-scale functional architecture

Biyu J. He; Abraham Z. Snyder; John M. Zempel; Matthew D. Smyth; Marcus E. Raichle

doi:10.1073/pnas.0807010105

Electrophysiological correlates of the brain's intrinsic large-scale functional architecture

Biyu J. He, Abraham Z. Snyder, John M. Zempel, Matthew D. Smyth, Marcus E. Raichle

Research output: Contribution to journal › Article › peer-review

537 Scopus citations

Abstract

Spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signals demonstrate consistent temporal correlations within large-scale brain networks associated with different functions. The neurophysiological correlates of this phenomenon remain elusive. Here, we show in humans that the slow cortical potentials recorded by electrocorticography demonstrate a correlation structure similar to that of spontaneous BOLD fluctuations across wakefulness, slow-wave sleep, and rapid-eye-movement sleep. Gamma frequency power also showed a similar correlation structure but only during wakefulness and rapid-eye-movement sleep. Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology.

Original language	English
Pages (from-to)	16039-16044
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	105
Issue number	41
DOIs	https://doi.org/10.1073/pnas.0807010105
State	Published - Oct 14 2008

Keywords

Electrocorticography
Functional connectivity
Human
Sleep
fMRI

Access to Document

10.1073/pnas.0807010105

Cite this

@article{7b8a8243aca54ea8a89479d2e060464d,

title = "Electrophysiological correlates of the brain's intrinsic large-scale functional architecture",

abstract = "Spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signals demonstrate consistent temporal correlations within large-scale brain networks associated with different functions. The neurophysiological correlates of this phenomenon remain elusive. Here, we show in humans that the slow cortical potentials recorded by electrocorticography demonstrate a correlation structure similar to that of spontaneous BOLD fluctuations across wakefulness, slow-wave sleep, and rapid-eye-movement sleep. Gamma frequency power also showed a similar correlation structure but only during wakefulness and rapid-eye-movement sleep. Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology.",

keywords = "Electrocorticography, Functional connectivity, Human, Sleep, fMRI",

author = "He, {Biyu J.} and Snyder, {Abraham Z.} and Zempel, {John M.} and Smyth, {Matthew D.} and Raichle, {Marcus E.}",

year = "2008",

month = oct,

day = "14",

doi = "10.1073/pnas.0807010105",

language = "English",

volume = "105",

pages = "16039--16044",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

number = "41",

}

TY - JOUR

T1 - Electrophysiological correlates of the brain's intrinsic large-scale functional architecture

AU - He, Biyu J.

AU - Snyder, Abraham Z.

AU - Zempel, John M.

AU - Smyth, Matthew D.

AU - Raichle, Marcus E.

PY - 2008/10/14

Y1 - 2008/10/14

N2 - Spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signals demonstrate consistent temporal correlations within large-scale brain networks associated with different functions. The neurophysiological correlates of this phenomenon remain elusive. Here, we show in humans that the slow cortical potentials recorded by electrocorticography demonstrate a correlation structure similar to that of spontaneous BOLD fluctuations across wakefulness, slow-wave sleep, and rapid-eye-movement sleep. Gamma frequency power also showed a similar correlation structure but only during wakefulness and rapid-eye-movement sleep. Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology.

AB - Spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signals demonstrate consistent temporal correlations within large-scale brain networks associated with different functions. The neurophysiological correlates of this phenomenon remain elusive. Here, we show in humans that the slow cortical potentials recorded by electrocorticography demonstrate a correlation structure similar to that of spontaneous BOLD fluctuations across wakefulness, slow-wave sleep, and rapid-eye-movement sleep. Gamma frequency power also showed a similar correlation structure but only during wakefulness and rapid-eye-movement sleep. Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology.

KW - Electrocorticography

KW - Functional connectivity

KW - Human

KW - Sleep

KW - fMRI

UR - http://www.scopus.com/inward/record.url?scp=57349194220&partnerID=8YFLogxK

U2 - 10.1073/pnas.0807010105

DO - 10.1073/pnas.0807010105

M3 - Article

C2 - 18843113

AN - SCOPUS:57349194220

SN - 0027-8424

VL - 105

SP - 16039

EP - 16044

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 41

ER -

Electrophysiological correlates of the brain's intrinsic large-scale functional architecture

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this