Electrophysiological correlates of the brain's intrinsic large-scale functional architecture

Biyu J. He, Abraham Z. Snyder, John M. Zempel, Matthew D. Smyth, Marcus E. Raichle

Research output: Contribution to journalArticlepeer-review

491 Scopus citations


Spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signals demonstrate consistent temporal correlations within large-scale brain networks associated with different functions. The neurophysiological correlates of this phenomenon remain elusive. Here, we show in humans that the slow cortical potentials recorded by electrocorticography demonstrate a correlation structure similar to that of spontaneous BOLD fluctuations across wakefulness, slow-wave sleep, and rapid-eye-movement sleep. Gamma frequency power also showed a similar correlation structure but only during wakefulness and rapid-eye-movement sleep. Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology.

Original languageEnglish
Pages (from-to)16039-16044
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number41
StatePublished - Oct 14 2008


  • Electrocorticography
  • Functional connectivity
  • Human
  • Sleep
  • fMRI


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