TY - JOUR
T1 - Electrophysiological Characterization of Substantia Nigra Pars Reticulata in Anesthetized Rats
AU - Liu, Xinrui
AU - Zhang, Qianwen
AU - Wang, Ying
AU - Chen, Fujun
N1 - Publisher Copyright:
© 2022, Shanghai Jiao Tong University.
PY - 2022/8
Y1 - 2022/8
N2 - The substantia nigra pars reticulate (SNr), which plays a pivotal role in motor control, is the key structure in integrating information for cortex, basal ganglia and thalamus. Abnormal gait and posture deficits can be reversed by SNr deep brain stimulation (DBS) in certain Parkinson’s disease cases. However, functional characterization of SNr, which is the key for the optimization of DBS effect, remains elusive. In current study, we recorded extracellular single unit in SNr of urethane anesthetized rats. We have found that urethane can induce slow delta and theta oscillations in SNr local field potential. The high gamma oscillation observed is positively correlated with the occurrence of action potential. The putative GABAergic neurons have a mean firing rate of (20.82 ± 2.04) Hz, of which 65.2% display a regular firing pattern and 34.8% show irregular firing. Our results demonstrated the heterogeneous property of SNr and provided possible theoretical basis for promoting the next generation of DBS electrode design and optimization of clinical DBS parameters.
AB - The substantia nigra pars reticulate (SNr), which plays a pivotal role in motor control, is the key structure in integrating information for cortex, basal ganglia and thalamus. Abnormal gait and posture deficits can be reversed by SNr deep brain stimulation (DBS) in certain Parkinson’s disease cases. However, functional characterization of SNr, which is the key for the optimization of DBS effect, remains elusive. In current study, we recorded extracellular single unit in SNr of urethane anesthetized rats. We have found that urethane can induce slow delta and theta oscillations in SNr local field potential. The high gamma oscillation observed is positively correlated with the occurrence of action potential. The putative GABAergic neurons have a mean firing rate of (20.82 ± 2.04) Hz, of which 65.2% display a regular firing pattern and 34.8% show irregular firing. Our results demonstrated the heterogeneous property of SNr and provided possible theoretical basis for promoting the next generation of DBS electrode design and optimization of clinical DBS parameters.
KW - A
KW - electrophysiology
KW - firing regularity
KW - local field potential
KW - Q 424
KW - substantia nigra pars reticulate (SNr)
UR - https://www.scopus.com/pages/publications/85130111170
U2 - 10.1007/s12204-022-2420-y
DO - 10.1007/s12204-022-2420-y
M3 - Article
AN - SCOPUS:85130111170
SN - 1007-1172
VL - 27
SP - 505
EP - 511
JO - Journal of Shanghai Jiaotong University (Science)
JF - Journal of Shanghai Jiaotong University (Science)
IS - 4
ER -