TY - JOUR
T1 - Electrophysiological actions of luteinizing hormone‐realeasing hormone
T2 - Intracellular studies in the rat hippocampal slice preparation
AU - Wong, Michael
AU - Eaton, Misty J.
AU - Moss, Robert L.
PY - 1990
Y1 - 1990
N2 - The electrophysilogical effects of luteinizing hormone‐releasing hormone (LHRH) on CA1 pyramidal cells were investigated utilizing intracellular recodings from the in vitro rat hippocampal slce preparation. Bath application of LHRH (10‐7‐10‐12M) resulted in several changes in the electrophysiological properties of CA1 neurons. LHRH induced a long‐lasting depolarization associated with increased input resitance, and decrease in the afterhyperpolarization associated with increased input resistance, ad decrease in the afterhyperpolarization (AHP) following a train of action potentials, and a reduction in accommodation of repetitive cell discharge. These effects were blocked by the synthetic LHRH antagonist [Ac‐δ‐Pro1, pCl‐D‐Phe2, D‐Trp3,6]‐LHRH. These findings provide electrophysiological evidence for the role of LHRH as a neurotransmitter/neuromodulator in the hippocampus.
AB - The electrophysilogical effects of luteinizing hormone‐releasing hormone (LHRH) on CA1 pyramidal cells were investigated utilizing intracellular recodings from the in vitro rat hippocampal slce preparation. Bath application of LHRH (10‐7‐10‐12M) resulted in several changes in the electrophysiological properties of CA1 neurons. LHRH induced a long‐lasting depolarization associated with increased input resitance, and decrease in the afterhyperpolarization associated with increased input resistance, ad decrease in the afterhyperpolarization (AHP) following a train of action potentials, and a reduction in accommodation of repetitive cell discharge. These effects were blocked by the synthetic LHRH antagonist [Ac‐δ‐Pro1, pCl‐D‐Phe2, D‐Trp3,6]‐LHRH. These findings provide electrophysiological evidence for the role of LHRH as a neurotransmitter/neuromodulator in the hippocampus.
KW - Accommodation
KW - Afterhyperpolarization
KW - Ca1 neurons
KW - Neuropeptide
UR - http://www.scopus.com/inward/record.url?scp=0025270464&partnerID=8YFLogxK
U2 - 10.1002/syn.890050106
DO - 10.1002/syn.890050106
M3 - Article
C2 - 2405538
AN - SCOPUS:0025270464
SN - 0887-4476
VL - 5
SP - 65
EP - 70
JO - Synapse
JF - Synapse
IS - 1
ER -