Electroconvulsive shock increases endogenous monoamine oxidase inhibitor activity in brain and cerebrospinal fluid

Lawrence Isaac; Ronald Schoenbeck; John Bacher; Phil Skolnick; Steven M. Paul

doi:10.1016/0304-3940(86)90028-5

Electroconvulsive shock increases endogenous monoamine oxidase inhibitor activity in brain and cerebrospinal fluid

Lawrence Isaac, Ronald Schoenbeck, John Bacher, Phil Skolnick, Steven M. Paul

Washington University School of Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Chronic daily administration of electroconvulsive shock (ECS) to cats resulted in a progressive elevation of seizure threshold which was accompanied by a sustained elevation in the activity of an endogenous monoamine oxidase inhibitor (EMAOI) present in cerebrospinal fluid (CSF). The increase in EMAOI activity in CSF following chronic ECS was observed maximally at 24-48 h. In rats, a single application of ECS resulted in a rapid but short-lasting increase in EMAOI activity present in the crude membrane fraction from brain. These findings demonstrate that both acute and chronic ECS modify the activity of an EMAOI in brain and CSF which may contribute to both the antidepressant and anticonvulsant effects of ECS treatment.

Original language	English
Pages (from-to)	257-262
Number of pages	6
Journal	Neuroscience Letters
Volume	66
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(86)90028-5
State	Published - May 23 1986

Keywords

MAO
brain
cat
electroconvulsive shock
endogenous monoamine oxidase inhibitor
monoamine oxidase
rat

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10.1016/0304-3940(86)90028-5

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abstract = "Chronic daily administration of electroconvulsive shock (ECS) to cats resulted in a progressive elevation of seizure threshold which was accompanied by a sustained elevation in the activity of an endogenous monoamine oxidase inhibitor (EMAOI) present in cerebrospinal fluid (CSF). The increase in EMAOI activity in CSF following chronic ECS was observed maximally at 24-48 h. In rats, a single application of ECS resulted in a rapid but short-lasting increase in EMAOI activity present in the crude membrane fraction from brain. These findings demonstrate that both acute and chronic ECS modify the activity of an EMAOI in brain and CSF which may contribute to both the antidepressant and anticonvulsant effects of ECS treatment.",

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AU - Isaac, Lawrence

AU - Schoenbeck, Ronald

AU - Bacher, John

AU - Skolnick, Phil

AU - Paul, Steven M.

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AB - Chronic daily administration of electroconvulsive shock (ECS) to cats resulted in a progressive elevation of seizure threshold which was accompanied by a sustained elevation in the activity of an endogenous monoamine oxidase inhibitor (EMAOI) present in cerebrospinal fluid (CSF). The increase in EMAOI activity in CSF following chronic ECS was observed maximally at 24-48 h. In rats, a single application of ECS resulted in a rapid but short-lasting increase in EMAOI activity present in the crude membrane fraction from brain. These findings demonstrate that both acute and chronic ECS modify the activity of an EMAOI in brain and CSF which may contribute to both the antidepressant and anticonvulsant effects of ECS treatment.

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Electroconvulsive shock increases endogenous monoamine oxidase inhibitor activity in brain and cerebrospinal fluid

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