Electro-acupuncture improves behavior and upregulates GDNF mRNA in MFB transected rats

Xi Bin Liang, Yong Luo, Xian Yu Liu, Jun Lu, Feng Qiao Li, Qian Wang, Xiao Min Wang, Ji Sheng Han

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


Low and high frequency electro-acupuncture (EA) stimulation was used in rats that had been lesioned by medial forebrain bundle transection. Behavioral tests showed that both low and high frequency EA stimulation significantly reduced the amphetamine-induced rotation 2 weeks after the lesion but only high frequency EA improved the rotational behavior at 4 weeks. Analysis of the dopamine content in the striatum did not show any significant change after EA. In situ hybridization showed that high frequency EA stimulation up-regulated the glial cell line-derived neurotrophic factor (GDNF) mRNA in both sides of the globus pallidus, while low frequency EA only affected the unlesioned side. It suggests that the retrograde nourishment of GDNF to the dopaminergic neurons and the balanced activity of different nuclei in the basal ganglia circuit after EA may contribute to the behavioral improvement in these rats, which might be the factors that underlie the effectiveness of EA in the treatment of Parkinson's disease.

Original languageEnglish
Pages (from-to)1177-1181
Number of pages5
Issue number8
StatePublished - Jun 11 2003


  • Electro-acupuncture
  • Glial cell-line-derived neurotrophic factor
  • Parkinson's disease
  • Rat
  • Regeneration


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