Electrical resynchronization: A novel therapy for the failing right ventricle

Anne M. Dubin, Jeffrey A. Feinstein, V. Mohan Reddy, Frank L. Hanley, George F. Van Hare, David N. Rosenthal

Research output: Contribution to journalArticle

181 Scopus citations

Abstract

Background - Many patients with congenital heart disease develop right ventricular (RV) failure due to anatomy and prior therapy. RV problems may include right bundle-branch block (RBBB), volume loading, and chamber enlargement. Because the failing RV may have regional dyskinesis, we hypothesized that resynchronization therapy might augment its performance. Methods and Results - We studied 7 patients with RV dysfunction and RBBB, using a predefined pacing protocol. QRS duration, cardiac index (CI), and RV dP/dt were measured in 4 different pacing states. Atrioventricular pacing improved CI and RV dP/dtmax and decreased QRS duration as compared with atrial pacing or sinus rhythm. Conclusions - Atrioventricular pacing in patients with RBBB and RV dysfunction augments RV and systemic performance. RV resynchronization is a promising novel therapy for patients with RV failure.

Original languageEnglish
Pages (from-to)2287-2289
Number of pages3
JournalCirculation
Volume107
Issue number18
DOIs
StatePublished - May 13 2003
Externally publishedYes

Keywords

  • Heart defects, congenital
  • Heart failure
  • Pacing

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    Dubin, A. M., Feinstein, J. A., Reddy, V. M., Hanley, F. L., Van Hare, G. F., & Rosenthal, D. N. (2003). Electrical resynchronization: A novel therapy for the failing right ventricle. Circulation, 107(18), 2287-2289. https://doi.org/10.1161/01.CIR.0000070930.33499.9F