Elastolysis of normal and partially cross-linked elastin.

K. Bostancioglu, R. P. Mecham, J. M. Wallach

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Rate of elastolysis by pancreatic and leukocyte elastases of normal and copper deficient porcine aortic elastins were measured using a conductimetric method. Kinetics obey to Michaelis-Menten model for both substrates and enzymes. KM and Vmax values derived from Lineweaver-Burk plots indicate that, if a near uniformity exists in KM, differences were observed in catalytic rates, kcat increasing approximately 40% for copper deficient elastin elastolysis by leukocyte elastase. This higher susceptibility to proteolysis may have implications for understanding turnover of elastin in tissues.

Original languageEnglish
Pages (from-to)263-269
Number of pages7
JournalBiochemistry International
Volume15
Issue number2
StatePublished - Aug 1987
Externally publishedYes

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