Abstract
Rate of elastolysis by pancreatic and leukocyte elastases of normal and copper deficient porcine aortic elastins were measured using a conductimetric method. Kinetics obey to Michaelis-Menten model for both substrates and enzymes. KM and Vmax values derived from Lineweaver-Burk plots indicate that, if a near uniformity exists in KM, differences were observed in catalytic rates, kcat increasing approximately 40% for copper deficient elastin elastolysis by leukocyte elastase. This higher susceptibility to proteolysis may have implications for understanding turnover of elastin in tissues.
| Original language | English |
|---|---|
| Pages (from-to) | 263-269 |
| Number of pages | 7 |
| Journal | Biochemistry International |
| Volume | 15 |
| Issue number | 2 |
| State | Published - Aug 1987 |
| Externally published | Yes |
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Bostancioglu, K., Mecham, R. P., & Wallach, J. M. (1987). Elastolysis of normal and partially cross-linked elastin. Biochemistry International, 15(2), 263-269.