Elastin in large artery stiffness and hypertension

Jessica E. Wagenseil, Robert P. Mecham

Research output: Contribution to journalArticle

175 Scopus citations

Abstract

Large artery stiffness, as measured by pulse wave velocity, is correlated with high blood pressure and may be a causative factor in essential hypertension. The extracellular matrix components, specifically the mix of elastin and collagen in the vessel wall, determine the passive mechanical properties of the large arteries. Elastin is organized into elastic fibers in the wall during arterial development in a complex process that requires spatial and temporal coordination of numerous proteins. The elastic fibers last the lifetime of the organism but are subject to proteolytic degradation and chemical alterations that change their mechanical properties. This review discusses how alterations in the amount, assembly, organization, or chemical properties of the elastic fibers affect arterial stiffness and blood pressure. Strategies for encouraging or reversing alterations to the elastic fibers are addressed. Methods for determining the efficacy of these strategies, by measuring elastin amounts and arterial stiffness, are summarized. Therapies that have a direct effect on arterial stiffness through alterations to the elastic fibers in the wall may be an effective treatment for essential hypertension.

Original languageEnglish
Pages (from-to)264-273
Number of pages10
JournalJournal of Cardiovascular Translational Research
Volume5
Issue number3
DOIs
StatePublished - Jun 1 2012

Keywords

  • Compliance
  • Extracellular matrix
  • Mechanics
  • Pulse wave velocity

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