TY - JOUR
T1 - Elastin
AU - Parks, William C.
AU - Pierce, Richard A.
AU - Lee, Katherine A.
AU - Mecham, Robert P.
N1 - Funding Information:
We thank our colleagues Drs. Charles Boyd and Mark Gibson for their permission to cite their unpublished data and Drs. Boyd and Edward Cleary for their contributions of figures. Our research is supported by NIH grants HL-48762, HL-41040, HL-26499, HL-41926, and HL-07317, and grants from the Dermatology Foundation and the American Heart Association. Dr. Parks is a Genetech/American Lung Association Career Investigator.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - This chapter reviews many of the characteristics of elastin and discusses several recent findings related to its regulation, interaction with cells, gene structure, and assembly. The understanding of elastin structure and elastic fiber assembly and function is expanding rapidly because of advances in cell and molecular biology. The recent characterization of the elastin gene has provided the tools with which to delineate the cellular controls of elastogenesis. The precise developmental expression of tropoelastin makes this an appropriate model for studying tissue- and temporalspecific regulation at the molecular level. Progress should be made in coming years on describing these mechanisms, and on determining the contribution of different regulatory processes to the control of elastogenesis. In addition, new in vitro models are being developed by many laboratories that can be used to delineate the influence of various factors and conditions on elastin-producing cells. Such models will provide further insights into the mechanisms by which cells interact with, and are influenced by, the extracellular matrix.
AB - This chapter reviews many of the characteristics of elastin and discusses several recent findings related to its regulation, interaction with cells, gene structure, and assembly. The understanding of elastin structure and elastic fiber assembly and function is expanding rapidly because of advances in cell and molecular biology. The recent characterization of the elastin gene has provided the tools with which to delineate the cellular controls of elastogenesis. The precise developmental expression of tropoelastin makes this an appropriate model for studying tissue- and temporalspecific regulation at the molecular level. Progress should be made in coming years on describing these mechanisms, and on determining the contribution of different regulatory processes to the control of elastogenesis. In addition, new in vitro models are being developed by many laboratories that can be used to delineate the influence of various factors and conditions on elastin-producing cells. Such models will provide further insights into the mechanisms by which cells interact with, and are influenced by, the extracellular matrix.
UR - http://www.scopus.com/inward/record.url?scp=77956735451&partnerID=8YFLogxK
U2 - 10.1016/S1569-2558(08)60201-5
DO - 10.1016/S1569-2558(08)60201-5
M3 - Article
AN - SCOPUS:77956735451
SN - 1569-2558
VL - 6
SP - 133
EP - 181
JO - Advances in Molecular and Cell Biology
JF - Advances in Molecular and Cell Biology
IS - C
ER -