Effort-Cost Decision-Making in Psychotic and Mood Disorders

Avolition and anhedonia are core symptoms across psychosis and mood disorders. One important mechanism thought to relate to these symptoms is effort-cost decision-making (ECDM), the valuation and estimation of work required to obtain a given reward. While recent work suggests impairments in ECDM in both mood disorders and psychosis relative to controls, limited work has taken a transdiagnostic approach to examine how these deficits relate to different symptom profiles across disorders. The present study investigated ECDM across schizophrenia/schizoaffective disorder (N = 33), bipolar disorder (N = 47), unipolar depression (N = 61), and healthy controls (N = 58) to examine willingness to expend physical effort. Moreover, we examined the relationship between ECDM and motivation and pleasure symptoms across participants. We found that people with schizophrenia and bipolar disorder showed a reduced willingness to expend physical effort at high reward values relative to controls, while as a group, those with depression showed no differences relative to controls. However, individual differences in self-reported motivation and pleasure predicted reduced ECDM, particularly at high reward values, suggesting that both severity of symptoms and diagnostic categories are important for understanding altered ECDM in psychopathology.