Efficient immune responses in mice lacking N‐region diversity

Susan Gilfillan, Martin Bachmann, Sylvie Trembleau, Luciano Adorini, Ulrich Kalinke, Rolf Zinkernagel, Christophe Benoist, Diane Mathis

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66 Scopus citations


Mice with a null mutation in the terminal deoxynucleotidyl transferase (TdT) gene harbor immunoglobulin and T cell receptor repertoires essentially devoid of N‐region diversity. Consequently, the CDR3 loops important for antigen recognition are shorter and considerably less diverse than those of wild‐type controls. We find surprisingly normal immune responses in TdT° mice, as regards both efficiency and specificity. This provokes a reconsideration of the assumption that N‐region diversity is required for an effective T and B cell repertoire.

Original languageEnglish
Pages (from-to)3115-3122
Number of pages8
JournalEuropean Journal of Immunology
Issue number11
StatePublished - Nov 1995


  • Knockout mice
  • N‐region diversity
  • T cell receptor
  • T cell repertoire
  • Terminal deoxynucleotidyl transferase


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