Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1

Eva Herker, Charles Harris, Céline Hernandez, Arnaud Carpentier, Katrin Kaehlcke, Arielle R. Rosenberg, Robert V. Farese, Melanie Ott

Research output: Contribution to journalArticle

211 Scopus citations

Abstract

Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection. DGAT1 interacts with the viral nucleocapsid core and is required for the trafficking of core to lipid droplets. Inhibition of DGAT1 activity or RNAi-mediated knockdown of DGAT1 severely impairs infectious virion production, implicating DGAT1 as a new target for antiviral therapy.

Original languageEnglish
Pages (from-to)1295-1298
Number of pages4
JournalNature medicine
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2010

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    Herker, E., Harris, C., Hernandez, C., Carpentier, A., Kaehlcke, K., Rosenberg, A. R., Farese, R. V., & Ott, M. (2010). Efficient hepatitis C virus particle formation requires diacylglycerol acyltransferase-1. Nature medicine, 16(11), 1295-1298. https://doi.org/10.1038/nm.2238