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Efficient and multiplexed somatic genome editing with Cas12a mice
Jess D. Hebert
, Haiqing Xu
, Yuning J. Tang
, Paloma A. Ruiz
, Colin R. Detrick
, Jing Wang
, Nicholas W. Hughes
, Oscar Donosa
, Vicky P. Siah
, Laura Andrejka
, Saswati Karmakar
, Irenosen Aboiralor
,
Rui Tang
, Rocio Sotillo
, Julien Sage
, Le Cong
, Dmitri A. Petrov
, Monte M. Winslow
Department of Neurosurgery
Roy and Diana Vagelos Division of Biology & Biomedical Sciences (DBBS)
DBBS - Cancer Biology
DBBS - Immunology
DBBS - Molecular Cell Biology
DBBS - Molecular Genetics and Genomics
DBBS - Neurosciences
Institute of Clinical and Translational Sciences (ICTS)
Brain Tumor Center
Siteman Cancer Center
Research output
:
Contribution to journal
›
Article
›
peer-review
4
Scopus citations
Overview
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Keyphrases
Multiplexing
100%
Cas12a
100%
Somatic Genome Editing
100%
Tumor
66%
Genetic Modification
66%
Tumor Suppressor Gene
66%
Mouse Model
33%
Transgenic Mice
33%
Gene Effects
33%
Genotype
33%
Genetic Disease
33%
Disease Model
33%
In Vivo Effects
33%
Multi-target
33%
Regulated Expression
33%
High-throughput
33%
Genetic Interaction
33%
Constitutive Expression
33%
Oncogenic Translocations
33%
Limited Ability
33%
Barcoding
33%
MiRNA Array
33%
CRISPR RNA (crRNA)
33%
Compound Genotype
33%
Biochemistry, Genetics and Molecular Biology
Genome Editing
100%
Cas12a
100%
Tumor Suppressor Gene
66%
Mouse Model
33%
Transgenic Mouse
33%
Allele
33%
Gene Mutation
33%
Carcinogenesis
33%
RNA
33%
CRISPR
33%
Gene Interaction
33%
Genomics
33%
Acidaminococcus
33%