Efficacité des agents topiques pour la prévention des maux de gorge postopératoires après une intubation avec tube endotrachéal simple lumière : une méta-analyse bayésienne en réseau

Translated title of the contribution: Efficacy of topical agents for prevention of postoperative sore throat after single lumen tracheal intubation: a Bayesian network meta-analysis

Narinder P. Singh, Jeetinder K. Makkar, Ron B. Cappellani, Ashish Sinha, Anand Lakshminarasimhachar, Preet Mohinder Singh

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Background: The optimal choice of prophylactic drugs to decrease postoperative sore throat is unclear. The objective of this network meta-analysis (NMA) was to compare and rank 11 topical agents used to prevent postoperative sore throat. Methods: Various databases were searched independently for randomized-controlled trials (RCTs) comparing topical agents used for the prevention of postoperative sore throat. Inclusion criteria were parallel group studies comparing intervention with active or inactive control and reporting postoperative sore throat. The primary outcome was postoperative sore throat at 24 hr. Secondary outcomes were early sore throat at 4–6 hr, cough, and hoarseness at 24 hr. Results: Evidence was synthesized from 70 RCTs reporting 7,141 patients. Topical application of lidocaine, corticosteroids, ketamine, magnesium, benzydamine, water-based lubricant, and liquorice applied along the tracheal tube, to the tracheal tube cuff, gargled or sprayed were compared with intracuff air and each other. Bayesian NMA showed that magnesium (odds ratio [OR], 0.10; 95% credible interval [CrI], 0.03 to 0.26), liquorice (OR, 0.14; 95% CrI, 0.03 to 0.55), and steroid application (OR, 0.11; 95% CrI, 0.06 to 0.22) most effectively prevented postoperative sore throat at 24 hr. Topical lidocaine was the least effective intervention. Conclusion: Topical application of magnesium followed by liquorice and corticosteroids most effectively prevented postoperative sore throat 24 hr after endotracheal intubation.

Translated title of the contributionEfficacy of topical agents for prevention of postoperative sore throat after single lumen tracheal intubation: a Bayesian network meta-analysis
Original languageFrench
Pages (from-to)1624-1642
Number of pages19
JournalCanadian Journal of Anesthesia
Volume67
Issue number11
DOIs
StatePublished - Nov 1 2020

Keywords

  • Cough
  • Hoarseness
  • Postoperative sore throat prophylaxis
  • topical agent
  • tracheal tube

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