Efficacy and Safety of Statins in Older Adults

Justin S. Sadhu; Michael W. Rich

doi:10.1007/s12170-012-0256-y

Efficacy and Safety of Statins in Older Adults

Justin S. Sadhu, Michael W. Rich

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Cardiovascular disease remains the leading cause of death in the United States, with the greatest burden borne by adults above 65 years of age. HMG-CoA-reductase inhibitors, or statins, have been demonstrated to greatly reduce morbidity and mortality in patients with established cardiovascular disease, yet their rates of utilization in older adults remain relatively low. In addition, few trials have specifically analyzed the efficacy of statins in older patients. This review summarizes the data relevant to the use of statins for the primary and secondary prevention of cardiovascular disease in older adults as well as some of the controversies regarding possible links between statins and cognitive impairment or diabetes.

Original language	English
Pages (from-to)	372-379
Number of pages	8
Journal	Current Cardiovascular Risk Reports
Volume	6
Issue number	5
DOIs	https://doi.org/10.1007/s12170-012-0256-y
State	Published - Oct 2012

Keywords

Adverse events
Coronary heart disease
Elderly
HMG-CoA reductase inhibitors
Hyperlipidemia
Lipids
Myocardial infarction
Primary prevention
Risk factors
Secondary prevention
Statins
Treatment

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10.1007/s12170-012-0256-y

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title = "Efficacy and Safety of Statins in Older Adults",

abstract = "Cardiovascular disease remains the leading cause of death in the United States, with the greatest burden borne by adults above 65 years of age. HMG-CoA-reductase inhibitors, or statins, have been demonstrated to greatly reduce morbidity and mortality in patients with established cardiovascular disease, yet their rates of utilization in older adults remain relatively low. In addition, few trials have specifically analyzed the efficacy of statins in older patients. This review summarizes the data relevant to the use of statins for the primary and secondary prevention of cardiovascular disease in older adults as well as some of the controversies regarding possible links between statins and cognitive impairment or diabetes.",

keywords = "Adverse events, Coronary heart disease, Elderly, HMG-CoA reductase inhibitors, Hyperlipidemia, Lipids, Myocardial infarction, Primary prevention, Risk factors, Secondary prevention, Statins, Treatment",

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AB - Cardiovascular disease remains the leading cause of death in the United States, with the greatest burden borne by adults above 65 years of age. HMG-CoA-reductase inhibitors, or statins, have been demonstrated to greatly reduce morbidity and mortality in patients with established cardiovascular disease, yet their rates of utilization in older adults remain relatively low. In addition, few trials have specifically analyzed the efficacy of statins in older patients. This review summarizes the data relevant to the use of statins for the primary and secondary prevention of cardiovascular disease in older adults as well as some of the controversies regarding possible links between statins and cognitive impairment or diabetes.

KW - Adverse events

KW - Coronary heart disease

KW - Elderly

KW - HMG-CoA reductase inhibitors

KW - Hyperlipidemia

KW - Lipids

KW - Myocardial infarction

KW - Primary prevention

KW - Risk factors

KW - Secondary prevention

KW - Statins

KW - Treatment

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DO - 10.1007/s12170-012-0256-y

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JO - Current Cardiovascular Risk Reports

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ER -

Efficacy and Safety of Statins in Older Adults

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Keywords

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