TY - JOUR
T1 - Efficacy and patient acceptance of pilocarpine gel
AU - Goldberg, Ivan
AU - Ashburn, Frank S.
AU - Kass, Michael A.
AU - Becker, Bernard
N1 - Funding Information:
From the Glaucoma Center, Department of Ophthalmology, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Missouri. This study was supported in part by grant EY 00336 from the National Eye Institute, Bethesda, Maryland, and by a grant from Fight For Sight, Inc., New York, New York (Dr. Goldberg).
PY - 1979/11
Y1 - 1979/11
N2 - Fifteen patients with symmetrically increased intraocular pressure (IOP) participated in a single-masked random 30-day clinical trial comparing 4% pilocarpine hydrochloride gel applied at bedtime to one eye with 4% pilocarpine hydrochloride drops instilled four times daily in the fellow eye. Both forms of pilocarpine reduced IOP significantly at 8 A.M., 12 noon, and 4 P.M. (P < .01). At these times there was no significant difference in effect between the two forms of pilocarpine (P > .05). The mean IOP of eyes treated with gel showed no significant difference from the pretreatment value at 10 P.M. (P = .37), whereas at this time eyes treated with drops did maintain a significant IOP reduction (P = .02). At 10 P.M. pilocarpine drops reduced IOP significantly more than did pilocarpine gel (P = .002). Pupil diameter was affected by the gel and drops in a similar pattern to that of IOP. Patients tolerated the gel with few side effects and were pleased by the convenience of administration once daily.
AB - Fifteen patients with symmetrically increased intraocular pressure (IOP) participated in a single-masked random 30-day clinical trial comparing 4% pilocarpine hydrochloride gel applied at bedtime to one eye with 4% pilocarpine hydrochloride drops instilled four times daily in the fellow eye. Both forms of pilocarpine reduced IOP significantly at 8 A.M., 12 noon, and 4 P.M. (P < .01). At these times there was no significant difference in effect between the two forms of pilocarpine (P > .05). The mean IOP of eyes treated with gel showed no significant difference from the pretreatment value at 10 P.M. (P = .37), whereas at this time eyes treated with drops did maintain a significant IOP reduction (P = .02). At 10 P.M. pilocarpine drops reduced IOP significantly more than did pilocarpine gel (P = .002). Pupil diameter was affected by the gel and drops in a similar pattern to that of IOP. Patients tolerated the gel with few side effects and were pleased by the convenience of administration once daily.
UR - http://www.scopus.com/inward/record.url?scp=0018702324&partnerID=8YFLogxK
U2 - 10.1016/0002-9394(79)90561-0
DO - 10.1016/0002-9394(79)90561-0
M3 - Article
C2 - 507163
AN - SCOPUS:0018702324
SN - 0002-9394
VL - 88
SP - 843
EP - 846
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 5
ER -