Effects of the volatile anesthetic agents on sinus node function and atrioventricular conduction in dogs: A comparison with chloralose anesthesia

Niall C.T. Wilton, Charles B. Hantler, Steven N. Landau, Lawrence O. Larson, Paul R. Knight

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The effects of equipotent concentrations (1.5 times minimum alveolar concentration) of the inhalational agents halothane, enflurane, and isoflurane on sinus node function, and atrioventricular (A-V) conduction and refractoriness were compared with chloralose anesthesia in 49 mongrel dogs. Sinus node function was assessed using corrected sinus node recovery time. Atrial-His and His-ventricular conduction times were measured at paced heart rates of 150, 180, and 200 beats/min, and A-V refractoriness was assessed by Wenckebach periodicity. There was no evidence that sinus node function was impaired by any of the inhalational agents. Enflurane anesthesia was associated with a significant prolongation of atrial-His conduction at paced heart rates of 180 and 200 beats/min when compared to chloralose anesthesia and the other two inhalational agents (P < .001). Atrioventricular refractoriness was impaired by enflurane (P < .001) and halothane (P < .05), but not isoflurane, when compared with chloralose anesthesia. Ventricular-His conduction was not altered by any of the agents. The authors conclude that enflurane is associated with a greater impairment of AN conduction and refractoriness than halothane or isoflurane, and that these changes are related to the anesthetic agent .and not the anesthetic state.

Original languageEnglish
Pages (from-to)188-193
Number of pages6
JournalJournal of Cardiothoracic Anesthesia
Volume2
Issue number2
DOIs
StatePublished - Apr 1988
Externally publishedYes

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