Effects of subarachnoid hemorrhage on cerebral blood volume, blood flow and oxygen utilization in humans

R. L. Grubb, M. E. Raichle, J. O. Eichling, M. H. Gado

Research output: Contribution to journalArticle

240 Scopus citations

Abstract

Forty five studies of regional cerebral blood volume (rCBV), regional cerebral blood flow (rCBF), and regional cerebral oxygen utilization (rCMRO2) were performed in 30 patients undergoing diagnostic cerebral angiography for evaluation of a subarachnoid hemorrhage due to a ruptured intracranial aneurysm. Tracer methods employing radioactive O15 were used to measure rCBV, rCBF, and rCMRO2. The patient studies were divided into groups based on their neurological status and the presence or absence of cerebral vasospasm. Subarachnoid hemorrhage, with and without vasospasm, produced significant decreases in CBF and CMRO2. In general, patients with more severe neurologic deficits, and patients with more severe degrees of vasospasm had a more marked depression of CBF and CMRO. The most striking finding was a significant (p<0.001) increase in CBV (to 58% above normal) in patients with severe neurologic deficits associated with severe cerebral vasospasm. This large increase suggests that cerebral vasospasm consists of constriction of the large, radiographically visible extraparenchymal vessels accompanied by a massive dilation of intraparenchymal vessels.

Original languageEnglish
Pages (from-to)446-453
Number of pages8
JournalJournal of neurosurgery
Volume46
Issue number4
DOIs
StatePublished - Jan 1 1977

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