Abstract
Background:Several studies have illustrated the efficacy of pregabalin in decreasing postoperative opioid use in adults undergoing orthognathic surgery. We aimed to study the effects of a single dose of preoperative pregabalin on total opioid consumption after orthognathic surgery in individuals with cleft lip and palate.Methods:This is a retrospective cohort study of consecutive patients who underwent Le Fort I midface advancement between June 2012 and July 2019. All patients had a diagnosis of cleft lip and palate. The treatment group received a 1-time preoperative dose of pregabalin; the control group did not. Total morphine milligram equivalent (MME) consumption was calculated by adding intraoperative and postoperative opioid use during admission.Results:Twenty-three patients were included in this study; 12 patients received pregabalin. The pregabalin group had significantly lower total opioid consumption (total MME 70.95 MME; interquartile range [IQR]: 24.65-150.17) compared to the control group (138.00 MME; IQR: 105.00-232.48) (MU=31.00, P=0.031). The difference in mean pain scores in the treatment group (3.21±2.03) and the control group (3.71±2.95) was not statistically significant (P=0.651, 95% confidence interval -1.75 to 2.75).Conclusions:A 1-time preoperative dose of pregabalin before orthognathic surgery in patients with cleft lip and palate reduced total opioid consumption during admission without increasing patient pain. A single preemptive dose of pregabalin should be considered an effective adjunct to pain management protocols in patients undergoing orthognathic surgery.
Original language | English |
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Pages (from-to) | 517-520 |
Number of pages | 4 |
Journal | Journal of Craniofacial Surgery |
Volume | 32 |
Issue number | 2 |
DOIs | |
State | Published - Mar 1 2021 |
Keywords
- Le Fort 1
- Pain management
- cleft lip
- cleft palate
- opioids
- orthognathic surgery
- pregabalin