Effects of Single-Dose Preoperative Pregabalin on Postoperative Pain and Opioid Consumption in Cleft Orthognathic Surgery

Abdullah M. Said, Ema Zubovic, Austin Y. Ha, Gary B. Skolnick, Sybill D. Naidoo, Jacob AuBuchon, Kamlesh B. Patel

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3 Scopus citations


Background:Several studies have illustrated the efficacy of pregabalin in decreasing postoperative opioid use in adults undergoing orthognathic surgery. We aimed to study the effects of a single dose of preoperative pregabalin on total opioid consumption after orthognathic surgery in individuals with cleft lip and palate.Methods:This is a retrospective cohort study of consecutive patients who underwent Le Fort I midface advancement between June 2012 and July 2019. All patients had a diagnosis of cleft lip and palate. The treatment group received a 1-time preoperative dose of pregabalin; the control group did not. Total morphine milligram equivalent (MME) consumption was calculated by adding intraoperative and postoperative opioid use during admission.Results:Twenty-three patients were included in this study; 12 patients received pregabalin. The pregabalin group had significantly lower total opioid consumption (total MME 70.95 MME; interquartile range [IQR]: 24.65-150.17) compared to the control group (138.00 MME; IQR: 105.00-232.48) (MU=31.00, P=0.031). The difference in mean pain scores in the treatment group (3.21±2.03) and the control group (3.71±2.95) was not statistically significant (P=0.651, 95% confidence interval -1.75 to 2.75).Conclusions:A 1-time preoperative dose of pregabalin before orthognathic surgery in patients with cleft lip and palate reduced total opioid consumption during admission without increasing patient pain. A single preemptive dose of pregabalin should be considered an effective adjunct to pain management protocols in patients undergoing orthognathic surgery.

Original languageEnglish
Pages (from-to)517-520
Number of pages4
JournalJournal of Craniofacial Surgery
Issue number2
StatePublished - Mar 1 2021


  • Le Fort 1
  • Pain management
  • cleft lip
  • cleft palate
  • opioids
  • orthognathic surgery
  • pregabalin


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