TY - JOUR
T1 - Effects of similarities in lifestyle habits on familial aggregation of high density lipoprotein and low density lipoprotein cholesterol
T2 - The NHLBI Family Heart Study
AU - Ellison, R. Curtis
AU - Myers, Richard H.
AU - Zhang, Yuqing
AU - Djoussé, Luc
AU - Knox, Sarah
AU - Williams, Roger R.
AU - Province, Michael A.
N1 - Funding Information:
and NO1-HC-25109 from the National Heart, Lung, and Blood Institute, Bethesda, Maryland. S.A.G.E. is supported by US Public Health Service resource grant 1 P41 RR03655 from the National Center for Research Resources.
PY - 1999/11/1
Y1 - 1999/11/1
N2 - It is generally assumed that familial aggregation of lipids relates to both genetic and shared environmental factors. To determine the degree to which familial similarities in lifestyle habits explain familial aggregation of high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol, the authors analyzed 1994-1996 data from 2,284 US adult participants in the National Heart, Lung, and Blood Institute Family Heart Study. For men and women, respectively, HDL cholesterol correlated with alcohol consumption (r = 0.27, p < 0.001; r = 0.21, p < 0.001), exercise (r = 0.06, p = 0.05; r = 0.10, p = 0.002), and smoking (r = -0.09, p = 0.005; r = -0.13, p < 0.001). There was strong familial aggregation of HDL cholesterol (parent-child, r = 0.32; sibling-sibling, r = 0.29), but less than 10% was explained by lifestyle habits. For LDL cholesterol, weak correlations were found for intake of total fat (r = 0.06, p = 0.07) and fruits/vegetables (r= -0.09, p = 0.005) among men and for smoking (r = 0.10, p = 0.002) among women. LDL cholesterol correlated strongly among family members (parent- child, r = 0.24; Sibling-sibling, r = 0.31), but essentially none of this aggregation related to the lifestyle factors studied. This study suggests that lifestyle factors have little effect on the familial aggregation of HDL and LDL cholesterol.
AB - It is generally assumed that familial aggregation of lipids relates to both genetic and shared environmental factors. To determine the degree to which familial similarities in lifestyle habits explain familial aggregation of high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol, the authors analyzed 1994-1996 data from 2,284 US adult participants in the National Heart, Lung, and Blood Institute Family Heart Study. For men and women, respectively, HDL cholesterol correlated with alcohol consumption (r = 0.27, p < 0.001; r = 0.21, p < 0.001), exercise (r = 0.06, p = 0.05; r = 0.10, p = 0.002), and smoking (r = -0.09, p = 0.005; r = -0.13, p < 0.001). There was strong familial aggregation of HDL cholesterol (parent-child, r = 0.32; sibling-sibling, r = 0.29), but less than 10% was explained by lifestyle habits. For LDL cholesterol, weak correlations were found for intake of total fat (r = 0.06, p = 0.07) and fruits/vegetables (r= -0.09, p = 0.005) among men and for smoking (r = 0.10, p = 0.002) among women. LDL cholesterol correlated strongly among family members (parent- child, r = 0.24; Sibling-sibling, r = 0.31), but essentially none of this aggregation related to the lifestyle factors studied. This study suggests that lifestyle factors have little effect on the familial aggregation of HDL and LDL cholesterol.
KW - Cholesterol coronary disease
KW - Genetics
KW - Medical
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=0033230151&partnerID=8YFLogxK
U2 - 10.1093/oxfordjournals.aje.a010099
DO - 10.1093/oxfordjournals.aje.a010099
M3 - Article
C2 - 10547136
AN - SCOPUS:0033230151
SN - 0002-9262
VL - 150
SP - 910
EP - 918
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 9
ER -