Effects of pharmacologic agents on human and canine pulmonary veins

Robert M. Smith; Brent M. Parker; G. Charles Oliver

doi:10.1016/0002-9149(70)90759-9

Effects of pharmacologic agents on human and canine pulmonary veins

Robert M. Smith, Brent M. Parker, G. Charles Oliver

Internal Medicine

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The effect of several pharmacologic agents on isolated human and canine pulmonary vein strips suspended from a force transducer was tested. Serotonin, norepinephrine and epinephrine caused contraction in most segments tested. Digitoxin was found to induce contraction of the pulmonary vein segments after a variable latent period. Tolazoline and aminophylline caused relaxation in a large number of the veins tested, although relaxation of human vein strips in response to tolazoline was less consistent. This study adds to the knowledge of the reactivity of human pulmonary veins.

Original language	English
Pages (from-to)	56-60
Number of pages	5
Journal	The American journal of cardiology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1016/0002-9149(70)90759-9
State	Published - Jul 1970

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abstract = "The effect of several pharmacologic agents on isolated human and canine pulmonary vein strips suspended from a force transducer was tested. Serotonin, norepinephrine and epinephrine caused contraction in most segments tested. Digitoxin was found to induce contraction of the pulmonary vein segments after a variable latent period. Tolazoline and aminophylline caused relaxation in a large number of the veins tested, although relaxation of human vein strips in response to tolazoline was less consistent. This study adds to the knowledge of the reactivity of human pulmonary veins.",

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AB - The effect of several pharmacologic agents on isolated human and canine pulmonary vein strips suspended from a force transducer was tested. Serotonin, norepinephrine and epinephrine caused contraction in most segments tested. Digitoxin was found to induce contraction of the pulmonary vein segments after a variable latent period. Tolazoline and aminophylline caused relaxation in a large number of the veins tested, although relaxation of human vein strips in response to tolazoline was less consistent. This study adds to the knowledge of the reactivity of human pulmonary veins.

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Effects of pharmacologic agents on human and canine pulmonary veins

Abstract

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