Effects of pharmacologic agents on human and canine pulmonary veins

Robert M. Smith, Brent M. Parker, G. Charles Oliver

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The effect of several pharmacologic agents on isolated human and canine pulmonary vein strips suspended from a force transducer was tested. Serotonin, norepinephrine and epinephrine caused contraction in most segments tested. Digitoxin was found to induce contraction of the pulmonary vein segments after a variable latent period. Tolazoline and aminophylline caused relaxation in a large number of the veins tested, although relaxation of human vein strips in response to tolazoline was less consistent. This study adds to the knowledge of the reactivity of human pulmonary veins.

Original languageEnglish
Pages (from-to)56-60
Number of pages5
JournalThe American journal of cardiology
Issue number1
StatePublished - Jul 1970


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