TY - JOUR
T1 - Effects of paradoxical sleep deprivation on thermoregulation in the rat
AU - Shaw, Paul J.
AU - Bergmann, Bernard M.
AU - Rechtschaffen, Allan
PY - 1998
Y1 - 1998
N2 - Rats were subjected to chronic paradoxical sleep deprivation (PSD) by the disk-over-water method to determine if they would develop the sustained increase in core (hypothalamic) temperature (T(hy)); elevated temperature set-point (T(set)); and the attenuation of the normal decline in core temperature during the transition from wake to sleep observed in rats subjected to total sleep deprivation (TSD). PSD rats did not show a significant elevation in T(hy). PSD rats and their yoked controls (PSC) were provided with a continuously available operant by which they could increase ambient temperature (T(amb)). Change in T(set) was assessed by evaluating operant behavior as a function of hypothalamic and intraperitoneal temperature (T(ip)). Unlike TSD rats, PSD and PSC rats maintained near- baseline T(amb) at all T(hy) and T(ip) values throughout the deprivation, indicating no change in T(set). As deprivation progressed, PSD rats displayed an attenuation of the normal fall of T(hy) and T(ip) during the transition from wake to sleep. PSC rats did not. During the final quarter of survival time, T(ip) in PSD rats actually rose above waking values during the transition to NREM. These results indicate that PS loss may alter thermoregulation during sleep. It would appear that selective PSD is sufficient to attenuate the normal decline in T(hy) and T(ip) during NREM sleep, whereas NREM loss is required for elevations in T(hy) and T(set).
AB - Rats were subjected to chronic paradoxical sleep deprivation (PSD) by the disk-over-water method to determine if they would develop the sustained increase in core (hypothalamic) temperature (T(hy)); elevated temperature set-point (T(set)); and the attenuation of the normal decline in core temperature during the transition from wake to sleep observed in rats subjected to total sleep deprivation (TSD). PSD rats did not show a significant elevation in T(hy). PSD rats and their yoked controls (PSC) were provided with a continuously available operant by which they could increase ambient temperature (T(amb)). Change in T(set) was assessed by evaluating operant behavior as a function of hypothalamic and intraperitoneal temperature (T(ip)). Unlike TSD rats, PSD and PSC rats maintained near- baseline T(amb) at all T(hy) and T(ip) values throughout the deprivation, indicating no change in T(set). As deprivation progressed, PSD rats displayed an attenuation of the normal fall of T(hy) and T(ip) during the transition from wake to sleep. PSC rats did not. During the final quarter of survival time, T(ip) in PSD rats actually rose above waking values during the transition to NREM. These results indicate that PS loss may alter thermoregulation during sleep. It would appear that selective PSD is sufficient to attenuate the normal decline in T(hy) and T(ip) during NREM sleep, whereas NREM loss is required for elevations in T(hy) and T(set).
KW - Behavioral temperature regulation
KW - Body temperature regulation
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=0031886417&partnerID=8YFLogxK
U2 - 10.1093/sleep/21.1.7
DO - 10.1093/sleep/21.1.7
M3 - Article
C2 - 9485528
AN - SCOPUS:0031886417
SN - 0161-8105
VL - 21
SP - 7
EP - 17
JO - Sleep
JF - Sleep
IS - 1
ER -