TY - JOUR
T1 - Effects of Ovarian Tissue Cryopreservation on Primary Ovarian Insufficiency in Girls Undergoing Bone Marrow Transplantation
AU - Dwiggins, Maggie
AU - Shim, Jessica
AU - Galloway, Lan Anh
AU - Hoefgen, Holly
AU - Patel, Vrunda
AU - Breech, Lesley
AU - Gomez-Lobo, Veronica
N1 - Publisher Copyright:
© 2022
PY - 2023/4
Y1 - 2023/4
N2 - Objective: To determine if removing an ovary for ovarian tissue cryopreservation (OTC) increased rates of primary ovarian insufficiency (POI) in girls undergoing bone marrow transplantation (BMT). Institutional review board approval was obtained from all 3 clinical sites. Design: Multicenter retrospective cohort study Setting: Academic children's hospitals Patients: Females aged 2-21 who underwent BMT with or without OTC from 2010 to 2017. Interventions: None Main Outcome Measures: Rates of POI in girls who underwent OTC vs those who underwent BMT alone as determined by serum markers, presence of menses, or clinical diagnosis. Results: A total of 142 patients were identified, 43 who had OTC and 99 with BMT alone. The rate of POI in girls undergoing OTC was 65% vs 41.8% in those who underwent BMT alone (P = .26). Conclusions: Although this study was not powered to detect a lack of difference, it is reassuring that there does not seem to be a clinically significant increase in POI in patients undergoing OTC.
AB - Objective: To determine if removing an ovary for ovarian tissue cryopreservation (OTC) increased rates of primary ovarian insufficiency (POI) in girls undergoing bone marrow transplantation (BMT). Institutional review board approval was obtained from all 3 clinical sites. Design: Multicenter retrospective cohort study Setting: Academic children's hospitals Patients: Females aged 2-21 who underwent BMT with or without OTC from 2010 to 2017. Interventions: None Main Outcome Measures: Rates of POI in girls who underwent OTC vs those who underwent BMT alone as determined by serum markers, presence of menses, or clinical diagnosis. Results: A total of 142 patients were identified, 43 who had OTC and 99 with BMT alone. The rate of POI in girls undergoing OTC was 65% vs 41.8% in those who underwent BMT alone (P = .26). Conclusions: Although this study was not powered to detect a lack of difference, it is reassuring that there does not seem to be a clinically significant increase in POI in patients undergoing OTC.
KW - Bone marrow transplant
KW - Fertility preservation
KW - Ovarian tissue cryopreservation
KW - Premature ovarian insufficiency
UR - http://www.scopus.com/inward/record.url?scp=85146444860&partnerID=8YFLogxK
U2 - 10.1016/j.jpag.2022.12.001
DO - 10.1016/j.jpag.2022.12.001
M3 - Article
C2 - 36481215
AN - SCOPUS:85146444860
SN - 1083-3188
VL - 36
SP - 128
EP - 133
JO - Journal of Pediatric and Adolescent Gynecology
JF - Journal of Pediatric and Adolescent Gynecology
IS - 2
ER -