TY - JOUR
T1 - Effects of nut consumption on selected inflammatory markers
T2 - a systematic review and meta-analysis of randomized controlled trials
AU - Xiao, Yunjun
AU - Xia, Junjie
AU - Ke, Yuebin
AU - Cheng, Jinquan
AU - Yuan, Jianhui
AU - Wu, Shuang
AU - Lv, Ziquan
AU - Huang, Suli
AU - Kim, Jean H.
AU - Wong, Samuel Yeung shan
AU - Yeoh, Eng kiong
AU - Colditz, Graham A.
AU - Su, Xuefen
N1 - Funding Information:
This work was supported by grants from the National Natural Science Foundation of China ( 81402672 ), Shenzhen Science and Technology Planning Project ( JCYJ20170306160008504 ), and Sanming Project of Medicine in Shenzhen ( SZSM201611068 ). YX and XS designed the study and drafted and revised the manuscript. YX, JX, YK, SW, ZL, and SH identified relevant articles and extracted and analyzed data. JC, JY, JHK, SYW, EK, and GAC commented and revised the manuscript. All of the authors read and approved the final manuscript. The authors have no conflicts of interest to declare.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/10
Y1 - 2018/10
N2 - Objective: Several randomized controlled trials (RCTs) have assessed the effects of nut consumption on inflammatory markers. However, the results have been inconsistent. The aim of this meta-analysis of RCTs was to quantitatively evaluate the effects of nut consumption on selected inflammatory markers. Methods: PubMed, Embase, Cochrane Library database, and Google Scholar were searched for published RCTs that reported the effects of nuts on inflammatory markers as primary or secondary outcomes in an adult population (aged ≥18 y). Summary estimates of weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated using random-effects meta-analysis. Results: Twenty-three RCTs met the inclusion criteria. Overall, nut consumption significantly reduced the levels of intercellular adhesion molecule (ICAM)-1 (WMD, −0.17; 95% CI, −0.32 to −0.03; P = 0.01), but had no significant effect on other inflammatory markers. In the subgroup analyses by nut types, mixed nuts had a significant effect on ICAM-1 reduction. The significant effect of nuts on ICAM-1 reduction was only observed in parallel, but not crossover RCTs. Additionally, nut consumption significantly reduced ICAM-1 and vascular cell adhesion molecule-1 levels in long-term (≥12 wk), but not short-term (<12 wk) RCTs. No significant heterogeneity or publication bias was observed in the studies included. Conclusions: Nut consumption significantly reduced ICAM-1 levels, but had no effect on other inflammatory markers. More studies are needed to assess the effects of nuts on inflammation.
AB - Objective: Several randomized controlled trials (RCTs) have assessed the effects of nut consumption on inflammatory markers. However, the results have been inconsistent. The aim of this meta-analysis of RCTs was to quantitatively evaluate the effects of nut consumption on selected inflammatory markers. Methods: PubMed, Embase, Cochrane Library database, and Google Scholar were searched for published RCTs that reported the effects of nuts on inflammatory markers as primary or secondary outcomes in an adult population (aged ≥18 y). Summary estimates of weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated using random-effects meta-analysis. Results: Twenty-three RCTs met the inclusion criteria. Overall, nut consumption significantly reduced the levels of intercellular adhesion molecule (ICAM)-1 (WMD, −0.17; 95% CI, −0.32 to −0.03; P = 0.01), but had no significant effect on other inflammatory markers. In the subgroup analyses by nut types, mixed nuts had a significant effect on ICAM-1 reduction. The significant effect of nuts on ICAM-1 reduction was only observed in parallel, but not crossover RCTs. Additionally, nut consumption significantly reduced ICAM-1 and vascular cell adhesion molecule-1 levels in long-term (≥12 wk), but not short-term (<12 wk) RCTs. No significant heterogeneity or publication bias was observed in the studies included. Conclusions: Nut consumption significantly reduced ICAM-1 levels, but had no effect on other inflammatory markers. More studies are needed to assess the effects of nuts on inflammation.
KW - Inflammatory markers
KW - Intercellular adhesion molecule
KW - Meta-analysis
KW - Nut consumption
KW - Randomized controlled trials
UR - https://www.scopus.com/pages/publications/85047616113
U2 - 10.1016/j.nut.2018.02.017
DO - 10.1016/j.nut.2018.02.017
M3 - Review article
C2 - 29852452
AN - SCOPUS:85047616113
SN - 0899-9007
VL - 54
SP - 129
EP - 143
JO - Nutrition
JF - Nutrition
ER -