Novel acetylenic and allenic steroid analogs previously have been synthesized in this laboratory and were shown to be potent irreversible inhibitors of Δ5-3- ketosteroid isomerase from P. testosteroni. This bacterial enzyme catalyzes the conversion of Δ5-3-ketosteroids to the corresponding Δ4-3-ketosteroids. These isomerizations are key steps in the mammalian biosynthesis of steroid hormones, and it was hoped that the acetylenic and allenic steroid analogs might inhibit androgen biosynthesis. It is now shown that these compounds cause a significant and dose-dependent decrease in the wet weight of both ventral and dorsal lateral prostate in the mature male rat.
|Number of pages||3|
|Journal||Cancer Treatment Reports|
|State||Published - Dec 1 1977|